ID M3W6P3_FELCA Unreviewed; 767 AA.
AC M3W6P3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=ITGB8 {ECO:0000313|Ensembl:ENSFCAP00000006400.3,
GN ECO:0000313|VGNC:VGNC:67857};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000006400.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000006400.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006400.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000006400.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006400.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000006400.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000006400.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR EMBL; AANG04003224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003982883.1; XM_003982834.4.
DR AlphaFoldDB; M3W6P3; -.
DR STRING; 9685.ENSFCAP00000006400; -.
DR PaxDb; 9685-ENSFCAP00000006400; -.
DR Ensembl; ENSFCAT00000006895.6; ENSFCAP00000006400.3; ENSFCAG00000006893.6.
DR GeneID; 101087724; -.
DR KEGG; fca:101087724; -.
DR CTD; 3696; -.
DR VGNC; VGNC:67857; ITGB8.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR HOGENOM; CLU_011772_3_1_1; -.
DR InParanoid; M3W6P3; -.
DR OMA; SKIDNPC; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000006893; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0034686; C:integrin alphav-beta8 complex; IEA:Ensembl.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:1990430; F:extracellular matrix protein binding; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0001573; P:ganglioside metabolic process; IEA:Ensembl.
DR GO; GO:0060022; P:hard palate development; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0061520; P:Langerhans cell differentiation; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1901388; P:regulation of transforming growth factor beta activation; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF9; INTEGRIN BETA-8; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 2.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 43..767
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004041629"
FT TRANSMEM 680..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 571..582
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS00022"
FT DISULFID 47..468
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 55..65
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 58..94
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 68..83
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 210..217
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 265..306
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 406..418
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 466..470
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 490..519
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 525..530
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 527..560
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 532..545
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 566..571
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 573..582
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 606..611
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 608..656
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 613..623
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 626..629
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 633..642
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 767 AA; 85549 MW; F54F2614AF967FD7 CRC64;
MCRSALAFFT AAFVCLQNCR PGPAPFLRAA WVFLVVLGLG QSEDNRCTSS NAASCTKCLA
LGPECGWCAQ EDFISGGSRS ERCDIISNLI SKGCSIDSIE YPSVHVIPSE NEMNTQVTPG
EVLIQLRPEA EANFMLKIHP LKKYPVDLYY LVDVSASMHN NIEKLNSVGN DLSRKMSYFS
RDFRLGFGSY VDKTVSPYIS IHPERIHNQC SDYNLDCMPP HGYIHVLSLT ENITEFEKAV
HRQKISGNID TPEGGFDAML QAAVCESHIG WRKEAKRLLL VMTDQTSHLA LDSKLAGIVV
PNDGNCHLKN NIYVRSTSME HPSLGQLSEK LIDNNINVIF AVQGKQFHWY KDLLPLLPGT
IAGEIESKAA NLNNLVVEAY QKLISEVKVQ VENQVKGVYF NITAICPDGT RKAGTDGCGN
VTSNDEVLFN VTVTMKKCDV TGGKSYAIIK PIGFNETTKI HIHRNCSCQC EDSRGPKRKC
IDEIFLDAKC FQCNENKCHF DEDQFPSESC KSHKDQPVCS GRGVCVCGKC LCHKIKLGKV
YGKYCEKDDF SCPYYHGNLC AGHGECEAGR CQCFSGWEGD RCQCPSASAQ HCVNPKGQVC
SGRGTCVCGK CQCTDPRSIG RFCEHCPTCH TACSENWNCV QCLHPHNLSQ AILDHCKTSC
ALTEQHYMDQ TSECFSSPSY LRIFFIIFIV TFLIGLLKVL IIRQVILQWN SNKIKSSADY
RVSASKKDKL ILQSVCTRTV TYRREKPEEI KMDISKLNAH ETFRCNF
//
