ID M3W8E5_FELCA Unreviewed; 954 AA.
AC M3W8E5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Chordin {ECO:0000256|ARBA:ARBA00016968, ECO:0000256|PIRNR:PIRNR002496};
GN Name=CHRD {ECO:0000313|Ensembl:ENSFCAP00000007223.5,
GN ECO:0000313|VGNC:VGNC:60870};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000007223.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000007223.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007223.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000007223.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007223.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000007223.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007223.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Dorsalizing factor. Key developmental protein that dorsalizes
CC early vertebrate embryonic tissues by binding to ventralizing TGF-beta
CC family bone morphogenetic proteins (BMPs) and sequestering them in
CC latent complexes. {ECO:0000256|PIRNR:PIRNR002496}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the chordin family.
CC {ECO:0000256|ARBA:ARBA00007156, ECO:0000256|PIRNR:PIRNR002496}.
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DR EMBL; AANG04001816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3W8E5; -.
DR STRING; 9685.ENSFCAP00000007223; -.
DR PaxDb; 9685-ENSFCAP00000007223; -.
DR Ensembl; ENSFCAT00000007801.6; ENSFCAP00000007223.5; ENSFCAG00000007799.6.
DR VGNC; VGNC:60870; CHRD.
DR eggNOG; ENOG502QR4J; Eukaryota.
DR GeneTree; ENSGT00940000161767; -.
DR HOGENOM; CLU_008477_0_0_1; -.
DR InParanoid; M3W8E5; -.
DR OMA; CCKSCPG; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000007799; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0036122; F:BMP binding; IBA:GO_Central.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:GO_Central.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0021513; P:spinal cord dorsal/ventral patterning; IEA:Ensembl.
DR Gene3D; 6.20.200.20; -; 1.
DR InterPro; IPR016353; Chordin.
DR InterPro; IPR010895; CHRD.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46526; CHORDIN; 1.
DR PANTHER; PTHR46526:SF1; CHORDIN; 1.
DR Pfam; PF07452; CHRD; 3.
DR Pfam; PF00093; VWC; 3.
DR PIRSF; PIRSF002496; Chordin; 1.
DR SMART; SM00754; CHRD; 4.
DR SMART; SM00214; VWC; 4.
DR SUPFAM; SSF57603; FnI-like domain; 4.
DR PROSITE; PS50933; CHRD; 4.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR002496};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..954
FT /note="Chordin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016383092"
FT DOMAIN 49..126
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 168..277
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 279..402
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 403..524
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 530..650
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 703..763
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 127..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 101495 MW; FB9C28603350118C CRC64;
MPSLPAPPAP LLLLGLLLLG CRPAHGAGPE PPALPIRSEK EPLPIRGAAG CSFGGKVYAL
DETWHPDLGE PFGVMRCVLC ACEAPQWGRR SRGPGRVSCK NIKPECPTLA CVQPRQLPGH
CCQTCPQERS GPERQPTGLA FEYPRDPEHR SYSDRGEPGS EDRTRGDGHT DFVALLTGPR
SQAVARARVS LLRSSLRFSI SYRQLDRPTR IRFSDSTGSV LFEHPAAPSQ DGLVCGVWRA
VPRLSLRLLR AEQLHVALVT PTNPSGEVWG PLIRHRALAA ETFSAILTLE GPPQPGTGGI
TLLTLSDTED SLHFLLLFRG LLEPRSGGPS QVPLRLQILH QGQLLRELYA NASVQEPGFA
EVLPNLTAQE MDWLVQGELT MALERAGGPG LRISGHIAAR QSCDVLQSVL CGADALIPVQ
TGAAGSASFT LLGNGSLIYQ VQVVGTGSEV VAMTLETKPQ RRNQRTVLCR MAGLQLGGHT
AVGVCPGLGA RGAHMLLQNE LFLNVGTKDF PDGELRGHVA ALPYSGHSTR HDTLPVPLAG
ALVLPPVQSQ AAGHAWLSLD THCHLHYEVL LAGLGGSEQG TVTAHLLGPP GMPGPRRLLK
GFYGPEAQGV VKDLEPELLR HLAQGTASLL ITTKGSPHGE LRGQVHIANQ CEVGGLRLAA
AGAEGAWAPD SAAAALPALP AVLGQDAPAP AKPGGPGRPR DPNTCFFEGQ QRPHGARWAP
NYDPLCSLCT CQRRTVICDP VVCPPPSCPS PVQAPDQCCP VCPEKQDVRD LSGLSRSRDP
GEGCYFDGDR SWRAAGTRWH PVVPPFGLIK CAVCTCKGGT GEVHCEKVQC PRLACAQPVR
ANPTDCCKQC PVGSGSHPQL GDPMQADGPR GCRFAGQWFP ESQSWHPSVP PFGEMSCITC
RCGAGVPHCE RDDCSLPLSC GPGKESRCCS HCSPRRSAPE TRTVPEPEKE AEGS
//
