ID M3WAW7_FELCA Unreviewed; 519 AA.
AC M3WAW7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=Heat shock 70 kDa protein 14 {ECO:0000256|ARBA:ARBA00018766};
GN Name=HSPA14 {ECO:0000313|VGNC:VGNC:84034};
GN Synonyms=MSANTD7 {ECO:0000313|Ensembl:ENSFCAP00000008487.5};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000008487.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000008487.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008487.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000008487.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008487.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000008487.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008487.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ribosome-associated complex (RAC), a complex
CC involved in folding or maintaining nascent polypeptides in a folding-
CC competent state. In the RAC complex, binds to the nascent polypeptide
CC chain, while DNAJC2 stimulates its ATPase activity.
CC {ECO:0000256|ARBA:ARBA00024825}.
CC -!- SUBUNIT: Component of ribosome-associated complex (RAC), a heterodimer
CC composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type
CC chaperone DNAJC2. {ECO:0000256|ARBA:ARBA00011347}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04002256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WAW7; -.
DR PaxDb; 9685-ENSFCAP00000008487; -.
DR Ensembl; ENSFCAT00000009156.6; ENSFCAP00000008487.5; ENSFCAG00000009154.6.
DR VGNC; VGNC:84034; HSPA14.
DR eggNOG; KOG0101; Eukaryota.
DR GeneTree; ENSGT00940000156380; -.
DR HOGENOM; CLU_005965_0_3_1; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000009154; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10238; HSPA14-like_NBD; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR042049; HSPA14_NBD.
DR PANTHER; PTHR19375:SF438; HEAT SHOCK 70 KDA PROTEIN 14; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
SQ SEQUENCE 519 AA; 56778 MW; 7B34B28C9299EA51 CRC64;
MGLSIYLYMS ICVLFSKDLI EFYFFFFFQD GRADVVANDA GDRVTPAVVA YTENEEVVGL
AAKQSRIRNI SNTVMKVKQI LGRSSDDPQA QKYITESKCL VIEKNGKLRY EIDTGEETKF
VNPEDVARLI FSKMKETAHS VLGSDANDVV ITVPFDFGEK QKNALGEAAR AAGFNVLRLI
HEPSAALLAY GIGQDCPTGK SNILVFKLGG TSLSVSVMEV NSGIYRVLST NTDDNIGGTH
FTETLAQYLA SEFQRSFKHD VRGNARAMMK LMNSADIAKH SLSTLGSANC FLDSLYEGQD
FDCNVSRARF ELLCSPLFNK CIEAIRELLE QSGFTADDIN KVVLCGGSSR IPRLQQLIKD
LFPNVELLNS VPPDEVIPIG AAIEAGILTG KENLLVKESL KIECSAKDIL VKGVDESGAK
SFTVLFPSGT PLPARRQHTL QAPGSISSVC LELYESEGKN SAKEEDKFAQ VVLQDLDKKE
NGLRDILAVL TMKRDGSLHV TCTDQETGKC EAITIEVAS
//
