ID M3WB07_FELCA Unreviewed; 4078 AA.
AC M3WB07;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=PKHD1 ciliary IPT domain containing fibrocystin/polyductin {ECO:0000313|Ensembl:ENSFCAP00000008545.4};
GN Name=PKHD1 {ECO:0000313|Ensembl:ENSFCAP00000008545.4,
GN ECO:0000313|VGNC:VGNC:68874};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000008545.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000008545.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008545.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000008545.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008545.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000008545.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008545.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011280663.1; XM_011282361.2.
DR RefSeq; XP_019686272.1; XM_019830713.1.
DR STRING; 9685.ENSFCAP00000008545; -.
DR PaxDb; 9685-ENSFCAP00000008545; -.
DR Ensembl; ENSFCAT00000009221.6; ENSFCAP00000008545.4; ENSFCAG00000009219.6.
DR GeneID; 101095100; -.
DR KEGG; fca:101095100; -.
DR CTD; 5314; -.
DR VGNC; VGNC:68874; PKHD1.
DR eggNOG; ENOG502QR85; Eukaryota.
DR GeneTree; ENSGT00940000160697; -.
DR HOGENOM; CLU_000057_1_0_1; -.
DR InParanoid; M3WB07; -.
DR OMA; QSCAINV; -.
DR OrthoDB; 4766at2759; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Bgee; ENSFCAG00000009219; Expressed in adult mammalian kidney and 3 other cell types or tissues.
DR GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR GO; GO:0045216; P:cell-cell junction organization; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:1904036; P:negative regulation of epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0010824; P:regulation of centrosome duplication; IEA:Ensembl.
DR GO; GO:1904054; P:regulation of cholangiocyte proliferation; IEA:Ensembl.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0090175; P:regulation of establishment of planar polarity; IEA:Ensembl.
DR GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
DR CDD; cd00603; IPT_PCSR; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 2.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF1; FIBROCYSTIN; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF07691; PA14; 1.
DR Pfam; PF01833; TIG; 8.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 5.
DR SMART; SM00710; PbH1; 7.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF81296; E set domains; 6.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..4078
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014174338"
FT TRANSMEM 3857..3880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 323..483
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 1931..2052
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 2746..2872
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT REGION 3906..3925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3910..3925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4078 AA; 447806 MW; 0E2D8889B3E55216 CRC64;
MTGWLISLMS AEILLLAVSS LRFHIEPEEG SLAGGTWITV LFDDLYLELL YPTNGSQLEI
HLVNVAVPGL PSIPCDVSPV FLDLPLVMCR TRSLLSEAHE GLYYLEVHSG GQVVGSPSPG
PQDNCTFQFS RGQTPIVYHV IPPSGVPGEL IHVYGWIITG RPETFDCDAE YIDSPLILEA
QGDNWVTACS LVNRQTGSCY PLQEDHGFGT LQCRVEGNYI GSQNVSFSVF NKGKSMVHKN
AWLVSAKQEL FLYQTYSEIL SVFPESGSLG GKTDIIITGD FFDNPARVTI AGIPCDIRHV
SPRKIECTTR APGKGARLTA PQAGNRGLLF EVGDAAEGLD LTAATSGYWW QIVPNASSPF
GFWSKEGQPF RARLSGFFVA PETNNYTFWV QADDQASLYL SQSEDPRTKV KVASISVGTA
DWFDAWEHHG NEGTWQRKTP KLELVGGTRY YLEAEHYGRV PRRGMRIGVQ IHNTWLNPAV
VSTYLREKHQ IRIRAQRLPE IQMLTLSGRR NFFLTWDNVF SQPVPENATA HQIQVAIEKL
LAVKCQLEPL SANILLWLGF EQGPEGSSFE GDLTSATEPY CGRFSLHQPR HLVLTPPAAQ
KGYRLDRYTH LCIAYRGHTT NILKVTMVFT TDFQNFVKKN ATCDWSLVGT SPNSWQFTCI
DLWESCVHHP EYSQLPLENS SVLVYQIDLL PLSQETSGFY VDEIIIADTN VTVSQADSGT
ACPGGNLVES LSVVGSPPVY NVSFWLAGCG QELPLITASS LPTEGEEEEP RLVQVTTQRI
QRASPPLGGY FRIQLPTTVI PDVPVSISAS HLRKLLQNNA DNFTSRYLNV SDFTVMEDLK
SCYERVWTLS WSNQVGDLPN FIRVSDENLT GVNPEATMRV VYDGGVFLGP IFGDMLVTAN
QCTQVVVHVN DIPAHCSGSC SFQYLEGSTP QVHSVWYSLD GDKDLLVYIF GTSFSIDPQA
LDVTVNKTNC RVIFSNQTNV VCQTQQLPVG MHPISMLVRP SGRAINASGE GLFLHVEPRL
DAVEPSRAAE IGGLWATVQG SGLEDVSLVL FGSQSCAINI TTNNSRRIQC KVPPRGKDGP
IVNVTVIRGD HSAVLPMAFT YVSSLNPVII SLSRNTSSIA GGETLFIGMA LLVNYTDLDV
EVCIQDTVAL VHVQMARGLE VVLPPLPVSL HRISVSINGI SIRSQGVDLH IRYITEVFSM
EPCCGSLLGG TILSISGIGF SRDPALVWVL VGNRSCDIVN STESIIWCET PPAALLPDAG
VPALPAPVEV WAGNVSFAQG PSPSLVGKGF TFMYEAGATP VVTAMRGEIT NSSLRLYVEG
NNLSNSVILL GVLNCDLETQ FLRNNMSLSG CSFPLHHLEA GIYPFQVRQK QMGFANMSAV
PQQFVMTPRI TAIWPTHGSA CGGTILTVRG LALKSRNRSV HVDLSGPFTC VILSLWDQTV
LCQINRVGDP LPDASFTLNI TVLVNGLPSE CQGNCTFFFQ EETTPIVDAL TTDISGSLTM
VLIRGQKLGI TADEPMVFVD NHLPCVVTFF NASHVSCWIS DLTPGLHYVS VVHTRNGYAC
FGNVSRHFYI LPQVFHYFPK NFSIHGGSLL TMKGTALRGE NSTLVYIGQQ ACLTVSISTK
LIQCVVPAGN GSVALVIEVD GLSYQMGAIG YSNAFTPELL SMSQADDILT FVVAQISGAA
NVDIFIGMSP CVGVSGNRTV LQCVVTSLPA GKYPVRGYDR SRGWASSVLV FTSTVTILAV
TENFGCLGGS LVHVFGAGFS PGNISAAVCG APCQVLANAT VSAFSCLVLP LDVSLAFLCG
LKHEEESCEA SSCTYVQCDL TVTVGTERLP QSWPYLYVCE EGPQCLLAPD HWTESTFPWF
SGLFISPKVE RDEVLIYNSS CNITMETEAK MECETPNQPI TAKITEIRKS RGQNTQGNFS
FQFCLRWSRA YSWFPERVPQ DGDNVTVENG QLLLLDTNTS ILSFLHVKGG KLIFMDPGPI
ELRVHSILIS DGGELRIGSK DKPFQGKAEI KLYGSSHSTP FFPYGVKFLA VRSGTLSLHG
SLPEVTVTHL RAAAYASDKV LALEDAVDWH SGDEVVIISG IGVKGAKPIE EMVIVDTVHT
TDLYLRSPLR YSHNFTESWV AGGRHILKVT VALLSRSVTI RGNLTTERMK HLASCQEASG
SEGNLQDCLY SKSEKMLGSR DLGARVIVQS FPEEPSRVQL KGVQFRDLGQ AFHRQLSSLT
LVGALRDSYI QGCTVWSSFS RGLSMSRTLG LKVDSNTFYN ILGHALLVGT DMDRRYTSWE
ATYERKIAWP VQGNIIRNNV IISVSGTEGL SSPEMLTPSG IYIRNPTNVV EGNRVYVAGL
GYFFHLVTSQ ASQSPLLSFS QNIAHSCTRC GLFVYPQFQP PWDNGKGLTV FQNFTVWGSA
GGAQIFRSSN LHLKNFQVYS CRDFGIDILE SDANTSVTDS LLLGHFAHKE SQCMSAGIKT
PKRRELIISN TTFVNFDLTD CVSIRTCSGC SQGQGGFPVK TDQLKFINSP NLVAFPFPYS
AILEDMDGSL SGRNRSHILA SMETLPASCL VNTSFSQIVH GSVCGEDVHF HRMSIGLANA
PDVPYDLIMT DSRNKTTIVN YVHDTLSNPY GWMALLLDQE TYSVQFENPW INRSLQYSAT
FGNFAPGNYL LLMHTVSWPY PDILIRCGSR VGQSLPSLPS PGQDQGCDWF FNTQLRQLTY
LVSGEGQVQV TLQVKEGVPP TISASTSAPK SALKWSLPEA WIGLEEGWGG HNHTIPGPGD
DVLILPNRTV LVDMNLPFLK GLYVMGTLEF PVDRSNVLSV ACMVIVGGEL KVGTLENPLG
KEQKLLILLR ASEGVFCDRF NGIHVDPGTI GVYGKVQLHG ACPKKSWTRL AADIAPGNER
IIVEDTVDWQ PHDKIILSSS SYEPHEAEVL TVKEVKAHHI RIYERLKHRH IGSVHVMEDG
RYIRLAAEVG LLTRNIQIQP DSSCRARLLV GSFRKSNSEE FSGVLQLSNV EIQNFGSSLY
SSIELTNASE GSWIISSTLH QSCGGGIRAA ASHGIVLNDN VVFGTVGHGI DLEGQNFSLS
NNLLVLMTQS SWSTVWVAGI KVNQAKNINL FGNVVAGSER LGFHIRGYRC SSPEARWSDN
VAHSSLHGLH LYKENGLDNC TCISGFLAFK NFDYGAMLHV ENSVEIENIT LVDNAIGLLA
TVYMSYAPQR HIENLQIVLR NSVIVATSSS FDCIQDRVKP RAANVTSTDR APSNPRGGRV
GILWPVFTSE PNQWPQEPWH RVRNDHSISG IMKIQDVTFS SFVKSCYNDD LDVCILPNVE
NTGIVHPITA ERTRMLNIKD NNKFYFPPLQ TRKSLGMLVC PESDCEDPRK YLFKDLDGRA
LGLPPPVSVF PKTEAEWTGS FFNTGTFREE QKCTYQPFIQ GYICKQTDQV ILILDNADAT
WTMQKLYPVV SVTNGFVDTF SSVNANTPCS TLGSVSSFYS ILPIREITKV CFVDQTPQIL
RFLLSGNKNT SKLLLAIFYH ELQSPRVFIG KSFIPPVLVQ STSSLLDESS GSNYFSILDN
LLYVVLQGQE PIEIRSGVSI HLAFTVIFPV LEKGWEILIL ERLTDFLQVS QNQIRFIHEM
PGSEATLKAI ADNKAKRKLN CPTVTCASHY RVGQRRPLMM ETSSYRILPP TTMETISKVV
VIEIGDLATI RSTGLISSLS SKKLQNLAHQ IITAQQTGVL ENVLNTTIGA LLVTQSKGIT
GYGNTSSFKT RNLIYIRPHA LSVLVQPSDG EVGKELRVQP QLVFLDKQNQ RIESLGPPSE
PWAISVSLEG TSDSVLKGCT QAESQDGYVS FSNLAVLISG SNWHFIFTVT SPPGANFTAR
SKSFVVSPAT MSEKSTIILA VSLCSVASWL ALCCLVCCWF KKSKSRKIKS GDISEFQTNG
QKNHIHISSK RQGSHVETEK EDTMMGEDRK MKVMVDKLNQ LPHQSLNGVS RRKVGHRAVQ
KEAGRQEEAV APALGLTSVP SQGHTCAPGS LAQHVYLQET GNWREAQEQL VRYQLAGQDQ
QLLLCPDFRQ ERQQLQGQSQ LGKERVSVGL SQEKRDSCGA TQAFSLHSVH PETIQEQL
//
