ID M3WEP4_FELCA Unreviewed; 1286 AA.
AC M3WEP4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=BMS1 ribosome biosis factor {ECO:0000313|Ensembl:ENSFCAP00000010424.5};
GN Name=BMS1 {ECO:0000313|Ensembl:ENSFCAP00000010424.5,
GN ECO:0000313|VGNC:VGNC:97367};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010424.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000010424.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010424.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000010424.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010424.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000010424.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010424.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; AANG04000273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011285715.1; XM_011287413.2.
DR STRING; 9685.ENSFCAP00000010424; -.
DR PaxDb; 9685-ENSFCAP00000010424; -.
DR Ensembl; ENSFCAT00000011225.6; ENSFCAP00000010424.5; ENSFCAG00000011220.6.
DR GeneID; 101101341; -.
DR KEGG; fca:101101341; -.
DR CTD; 9790; -.
DR VGNC; VGNC:97367; BMS1.
DR eggNOG; KOG1951; Eukaryota.
DR GeneTree; ENSGT00940000153195; -.
DR HOGENOM; CLU_002486_0_1_1; -.
DR InParanoid; M3WEP4; -.
DR OMA; KLHVPMV; -.
DR OrthoDB; 5478101at2759; -.
DR Proteomes; UP000011712; Chromosome D2.
DR Bgee; ENSFCAG00000011220; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR CDD; cd01882; BMS1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR037875; Bms1_N.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR PANTHER; PTHR12858:SF2; RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 80..245
FT /note="Bms1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51714"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..456
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..538
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..612
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1286 AA; 146676 MW; 9CE32F67D09A02DD CRC64;
METKDQKKHR KKNSGPKAEK KKKRHLQDLQ IGDEEDARKR NPKAFAVQSA VRMARSFHRT
QDLKTKKHHI PVVDRTPLEP PPIVVVVMGP PKVGKSTLIQ CLIRNFTRQK LTEIRGPVTI
VSGKKRRLTI IECGCDINMM IDLAKVADLV LMLIDASFGF EMETFEFLNI CQVHGFPKIM
GVLTHLDSFK YNKQLKKTKK RLKHRFWTEV YPGAKLFYLS GMVHGEYQNQ EIHNLGRFIT
VMKFRPLTWQ TSHPYILADR MEDLTNPEDI RKNIKCDRKV SLYGYLRGAH LKSKSQIHMP
GVGDFAVSDV SFLPDPCALP EQQKKRCLNE KEKLVYAPLS GVGGVLYDKD AVYVDLGGSH
GFQESDEVRP THELVQSLIS THSTIDAKMA SSRVTLFSDS KPLGSEDIDN QGHWMPKEER
QIDLETGRVR RKAIFGDEED ESGDSDEEDD EEMSEGDRLE NGSSADESEE EADAEMTNKM
YMVGKGVKRQ RLEEMEEDNE VDLPAFADSD DDLERSSEEE GDAEEADESS EEEDSTSGER
DSLESRVVGD RGKPGLLQTN GLSDSLNLEN PLTIRKATLT TSDSGHCTAE EAFASGDETE
EGSSLSTEDE DSENEEAIKK KFPESSKVAS GQRLGSENLI DETSDVEDLL KEEEDYKEEN
NYSTETSGAL KWKEDLSRKA AEAFLRQQQA TPNLRKLIYG TVTEDNEEED GDSREELGGL
FRVSQPSREC KHKLDSLDCS RFHVEAPHDW DLEEVMNSIR DCFVTGKWED DKDAAKILAE
DEELYGDFED LETGDVHKGK PGPDTQIEDV EEVKEEIDPN AEESAKKKHL DKKRKLKEMF
DAEYDEGEST YFDDLKGEMH KQAQLNRAEF EDQDDEARVQ YEGFRPGMYV RIEIENVPCE
FVLNFDPHYP MILGGLGNSE GNVGYVQMRL KKHRWYKKIL KSRDPIIFSV GWRRFQTIPL
YYIEDHNGRQ RLLKYTPQHM HCGATFWGPI TPQGTGFLAV QSVSGIMPDF RIAATGVVLD
LDKSIKIVKK LKLTGFPYKI FKNTSFIKGM FNSALEVAKF EGAVIRTVSG IRGQIKKALR
APEGAFRASF EDKLLMSDIV FMRTWYPVSI PAFYNPVTSL LKPVGEKDTW SGMRTTGQLR
LAHGVRLKPN KDSLYKPIMR QKKHFNSLHI PKALQKALPF KNKPKTQAKA GKIPKDRRRP
AVIREPHERK ILALLDALST VHSQKMKKAK EQRHLHNKEH FKVKQKEEEE KLKRQKDLRK
KLFRIQGQKE RRNQKSSLKG SGEPSK
//
