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Database: UniProt
Entry: M3WEZ1_FELCA
LinkDB: M3WEZ1_FELCA
Original site: M3WEZ1_FELCA 
ID   M3WEZ1_FELCA            Unreviewed;      1685 AA.
AC   M3WEZ1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   30-AUG-2017, entry version 38.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSFCAP00000010552};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010552, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000010552, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010552,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010552};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000010552}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010552};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000010552}.
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DR   EMBL; AANG02198434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000010552; -.
DR   Ensembl; ENSFCAT00000011360; ENSFCAP00000010552; ENSFCAG00000011354.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3WEZ1; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C1.
DR   Bgee; ENSFCAG00000011354; -.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF269; PTHR10037:SF269; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    236    259       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    368    392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    507    525       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    537    560       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    572    596       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    616    641       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    709    729       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    971    989       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1001   1018       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1060   1082       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1168   1195       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1244   1271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1283   1301       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1308   1327       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1372   1400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1476   1502       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      118    403       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      507    731       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      744    928       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      936   1200       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1252   1499       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1685 AA;  194013 MW;  FDBA116821101572 CRC64;
     EMASPEPKGL VPFTRESLEL MKQHIAKKHN EEQREDLKPN TDLEVGKELP FVYGNLPQGM
     VSEPLEDVDP YYKNKNNTFI VLNKKRTIFR FSATWCTFSP FSLTRRTTIK ILVHPPTFFR
     LFILISVLID CIFMPMTELP KWGPALQNTL LGIYTFEILI KLIARGIWVE PFYFFGDPWN
     WLDFSVTLFE HVTRYLPLNF IPIFRITRNL RILKIIPLNQ GLKSFVRILT HCLKKLTGVI
     ILTLFFLSVF SLIGMGLFMG NLKHKCLRWP QENETVTLHN RTENPYYIRE TENFYYLEGE
     IYALLCGNRT DAGQCPEGYV CVKAGTNPDY GFTNFDSFGW ALLALFRLMT QDYPEALYHQ
     ILYASGKVYM IFFVVISFWF AFYIASLFLG ILAMSCEEEK QKAAEKAEKT EPQFQQTLKE
     LQEGDKAAET KTTQIEMKKR SPTSMITSFN MLDDSTATVR HEEELKKSRK RRPLCLYRFA
     KTLLIWNCSP CWLKLKAFIH MIIMDPFTDL VLTICIILNV CFLALECYPM REETTSVLSI
     GNLIFIGIFT AEMILKIIAM HPYGYFQVGW NIFDSLIVFH GLAELYLANV SGMAFLKIFR
     VLRIFKLGKY WPTFRILMLI LSNSLVALKG LVLLLFTFMF FSAVVGLKLF GRSYKECVCN
     IDKDCQLPHW HMHDFFHSFL NVLRILCGEW IETLWDCLKV AGQFGCLPFY MMVILIGNLL
     IIYLFLALVS SFSSYKAPTT EENGEEQNLQ RAMARIKKGI NYVFPKISCK KQNISKETMD
     NVNNVYVREN ISDPTLSDVS NTQDFFKDKE KSSGTEKNTM TENESQSLIP SPSVSETVPI
     ASGESDIENL DNKEIQSKSG DGSSKEKVKQ SSSSECSTVD IAISEEETVC EHEKPKQLKN
     GYRRRSSPGQ ISGESKKGRI WQNIRKTCRK IVENGCFKCF IGLVTLLSTG ALAFEDIYID
     QRKTIKILLE YADMIFTYIF ILEMLLKWMA YGFKAYFTDS WYKLDFMVVI VFCLSLIGKS
     REEFKPLISV KFLRALRVLS QFERMKVVVR ALIKTTLPAL NVFLVCLMIW LAFSIIGVYL
     FAGTFYECID PTSGERFPVS EVMNKSQCES LVFNESMQWE NAKLNFDNVG NGFLSLLQVA
     TFNGWITIMN SAVDSTGVNK QPNFEDNIYM SCYFISFIVI GLFLPLSMLI GVIIANFNKH
     KIKQGGSNIF ITVKQKRQYH ALRGLLHEDS QKIIRRPRNK FQRFMFDLVT SQVFNVFIMV
     LICFQAITIM IQSDEQSSEM DTALYWITLF LVMVYTGECV LKLISFRCNY FTMGWNIFDF
     MVVIFSITDQ GLFLPLMVGY YLVPPSVVQL ILLSRIIHIL RPGKGPKVFR DLLLPLMLSF
     PALLNISLLI FLVMFVYAIF GMYNFAYVKK EFGINDVANF ETFGSSMLCL FQVTIFAGWD
     GMLNAIFNSK WSDCDPDKIN PGTQVRGDCG NPFVGIIYFV SYIFISWMII VNMYIIAVME
     FLNIASKKKA KTLSEDDFKK FFQVWKRFDP DRTQYIDSSK LSDLAAALDP PLFMAKPNKG
     QLVAMDLPMA AGDRIHCLDI LLALTKRVMG TDVRMEKVIS EMESGFALAN PFKIMYEPIT
     TTLKRKQEAV SATIIQRAYK NYRLRRNDKN TSDIHMIDDD KEVQATTENA YFDKAEEKLT
     IQSQI
//
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