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Database: UniProt
Entry: M3WF33_FELCA
LinkDB: M3WF33_FELCA
Original site: M3WF33_FELCA 
ID   M3WF33_FELCA            Unreviewed;      2025 AA.
AC   M3WF33;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   22-NOV-2017, entry version 34.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 6 {ECO:0000313|Ensembl:ENSFCAP00000010613};
GN   Name=TRPM6 {ECO:0000313|Ensembl:ENSFCAP00000010613};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000010613, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000010613, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010613,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000010613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010613};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000010613}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000010613};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000010613}.
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DR   EMBL; AANG02192883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02192891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFCAT00000011425; ENSFCAP00000010613; ENSFCAG00000011422.
DR   eggNOG; ENOG410INBW; Eukaryota.
DR   eggNOG; ENOG410ZSH9; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; M3WF33; -.
DR   OMA; NERMAMK; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   Proteomes; UP000011712; Chromosome D4.
DR   Bgee; ENSFCAG00000011422; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; IEA:Ensembl.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0030001; P:metal ion transport; IEA:Ensembl.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029597; TRPM6.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF15; PTHR13800:SF15; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    744    763       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    862       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    910    928       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    940    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    979    999       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1052   1075       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1752   1983       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
SQ   SEQUENCE   2025 AA;  231841 MW;  69F1E754940853A0 CRC64;
     KITTLSLQSQ KSWIEGVFNK RECSKIIPSS KDPHRCTAGC QVCQNLIRCY CGRLIGDHHG
     IDYSWTISAA NGNENEQWSV EKHTTKSPTD TFGTINFQDG EHTHHSKYIR TSYDTKADHL
     LHLMLKEWKM ELPKLVISVH GGIQNFRMPS KLKEIFSQGL VKAAETTGAW IITEGINTGV
     SKHVGDALKA HSFRSLRKIW TVGIPPWGVI ENQRDLIGKD VVCLYQTLGN PLSKLTTLNS
     MHSHFILSDD GTVGKYGNEM NLRRNLEKYL SLQKIHSRSR QGVPVVGLVV EGGPNVILAV
     WETVKDKDPV VVCEGTGRAA DLLAFTHKHL ADEGTLRPQV KEEIICMIQS TFNFSLKQSK
     HLFQILMECM VHRDSMTIFD ADSEESPDLD LVILTALLKG TNLAASEQLN LAMAWDRMDI
     AKKHILTYGQ HWKPGTLEQA MLDALVMDRV DFVKLLIEYG VNLHRFLTIP RLEELYNTKQ
     GPTNMLLHHL VRDVKQHALL SGYRITLIDI GLVIEYLIGG AYRSSYTRKS FRALYNNLYR
     KRKPPLHRRR PSGNRKESAE STLHSQFIRT AQPYKFKEKS VVLHKSRKKS KEEQNISDDP
     ESTGFIYPYN DLLVWAVLMK RQKMAMFFWQ HGEEATVKAV IACKLYRAMA HEAKESNMVD
     DASEELKNYS KQFGQLALDV LEKAFKQNER MAMKLLTYEL KNWSDSTCLK LAVSGRLRPF
     VSHTCTQMLL TDMWTGRLKM RKHAWLKIII SILFPPTILS LEFKSKAEMS HVPQSQDFQF
     AWYYGDQNAS NAKESAYTKD RDLERGPDEK LDENQHFDLK SGPQSLPWTR KIYEFYNAPI
     VKFWFYTMAY LAFLMLFTYT VLVEMQPQPS VQEWLVIIYI FTNAIEKVRE VCISEPGKFT
     QKVKVWISEY WNLIETVAIG LFSVGFGLRW GDPPLHTAGR LIYCIDIIFW FSRLLDFFAV
     NQHVGPYVTM IAKMTANMFY IVIMMAIVLL SFGVARKAIL SPKQLPSWSL ARDIVFEPYW
     MIYGEVYASD IDVCASHPSC PPGSFLTPFL QAVYLFVQYI IMVNLLIAFF NNVYVDMKSI
     SNKLWKYNRY RYIMTYHKKP WLPPPFILLS HVGLLLRRLC HHRAPNDQDE GDVGLKLYLS
     EEDLKRLHDF EEQCVEIYFH EKMERLNYSC EERIRVTSER VTEMYFQLKE MNEKVSFIKD
     SLLSLDSQVG HLQDLSALTV DTLKVLSAVD TLQEDEALLA NRKHSTCRKL PHSWNNVICA
     GVLGSMEISG EKKYQYYSMP PSLLRSLARG QHTLRVQRGP LLEITDIQRK ASNVRDEQEK
     QDTETSVVAS GVSLYTQTHP KHGQFLLVPS YLKQVPFSEE IDLPLFRPSM EAGIDVMATE
     QVAQNEVPVH LTWQTPGISA QGSVAEPKER YESIAHTPAR EDKGEQVPPT LICTPAPTQV
     TSVPSQAESM QVGGGYVNWA FSEGDETGVF SLKKKWQTCL ASTCSGEEND QCQKQIRVRS
     LSDNSSSLAQ SSDCSEVGPW LPPNTSFWIN PFRRDRPFTR SHSLRFHKEE KLKICRIKNL
     SRSSEIRQSA WIRTKMLIKD RRLSKKKKKT QGLQVPVIMV DTCSPNDQLN SEPGESNISE
     EEECSKNWLT VSKYSQQGLE PPIYQKMKTK EIERHAVQVS DYLKQSQEDL SKNSLWNSRS
     TSFNRNSLLR SSNGVDKISA SLKSPQEPHH HYSAIERNNL MRLSQTIPFT PIQLFAGEEV
     TVYRLEESSP LNLGKSMSSW SQRGRAAMIQ VLSREEMGGG LRKAMRVVST WSEDDVLRPG
     QVFIVKSFLP EVVQSWHRIF QESTVLHLCL REIQQQRAAQ KLIYTFNQVK PQTIPYTPRF
     LEVFLIYCHS ANQWLTIEKY MTGEFRKYNN NNGDEIAPSN TLEELLLAFS HWTYEYTRGE
     LLVLDLQGGV GENLTDPSVI KPEDKQSRGM VFGPANLGED AIRNFIAKHR CNSCCRKLKL
     PDLKRNDYSP GRLNSTFGLD TKIEPAEGPP AREGGGNSPE DLTRL
//
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