ID M3WFY0_FELCA Unreviewed; 864 AA.
AC M3WFY0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Dimethylglycine dehydrogenase {ECO:0000313|Ensembl:ENSFCAP00000011024.5};
GN Name=DMGDH {ECO:0000313|Ensembl:ENSFCAP00000011024.5,
GN ECO:0000313|VGNC:VGNC:61526};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011024.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011024.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011024.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011024.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011024.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011024.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011024.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; AANG04001174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WFY0; -.
DR STRING; 9685.ENSFCAP00000011024; -.
DR PaxDb; 9685-ENSFCAP00000011024; -.
DR Ensembl; ENSFCAT00000011885.6; ENSFCAP00000011024.5; ENSFCAG00000011882.6.
DR VGNC; VGNC:61526; DMGDH.
DR eggNOG; KOG2844; Eukaryota.
DR GeneTree; ENSGT00940000158176; -.
DR HOGENOM; CLU_007884_11_1_1; -.
DR InParanoid; M3WFY0; -.
DR OMA; NGWERPN; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000011882; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0047865; F:dimethylglycine dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042426; P:choline catabolic process; IEA:Ensembl.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 50..412
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 415..468
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 477..742
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 768..846
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
FT REGION 16..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 96556 MW; BDF6A62E3C1D4DF3 CRC64;
MLRPGAQRGL LLSSLRLQGS PGRPRSACGR QGEENTPLSA ETRWKDRAET VIIGGGCIGV
SLAYHLAKAG MKDVVLLEKS ELTAGSTWHA AGLTTYFHPG INLKKIHYAS IKLYEKLEEE
TGQVVGFHQP GSIRIATTPV RVDEFKYQMT RTGWHATEQY IIEPEKIQEM FPLLNMNKIL
AGLYNPGDGH IDPYSLTMAL AAGARKYGAL LKYPAPVTSL IPRSDGTWDV ETPQGSMRAN
RIVNAAGFWA REVGKMVGLE HPLIPVQHQY VVTSTIPEVK ALERELPVLR DLEGSYYLRQ
ERDGLLFGPY ESQEKMKVQD SWVTNGVPPG FGKELFESDL DRIMEHVEAA MEMVPVLKKA
DIINIVNGPI TYSPDILPMV GPHQGVRNYW VAIGFGYGII HAGGVGKYLS DWILHGEPPF
DLIELDPNRY GKWTTTQYTE AKARESYGFN NIVGYPKEER FAGRPTQRVS GLYKILESKC
SMGFHAGWEQ PHWFYKPGQD TRYRPSFRRT NWFEPVGSEY KQVMQSVGVI DLSPFGKFNI
KGQDSVRLLD HLFANVIPKV GFTNISHMLT PKGRVYAELT VSHQTPGEFL LITGSGSELH
DLRWIEEEAV NGGYDVEIKN ITDELGVLGI AGPHARKVLQ KLTSEDLSDD VFKFLQTKSL
MVSNIPVTAI RISYTGELGW ELYHRREDSV ALYDIIMNAG QEEGIDNFGT YAMNALRLEK
AFRAWGSEMN CDTNPLEAGL DYFIKLNKPA DFIGKQALKQ IKAKGLKRRL VCLTLATDDV
DPEGNESIWY DGKVVGNTTS GSYSYSVQKS LAFAYVPVEL SKVGQQVEVE LLGTNYPATV
IQEPLVLTEP ARNRLRKKNG KDTI
//
