ID M3WGV8_FELCA Unreviewed; 818 AA.
AC M3WGV8; A0A2I2UNW6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=ATP6V0A4 {ECO:0000313|Ensembl:ENSFCAP00000011509.6,
GN ECO:0000313|VGNC:VGNC:68718};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011509.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011509.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011509.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011509.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011509.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011509.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011509.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; AANG04000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WGV8; -.
DR Ensembl; ENSFCAT00000012409.6; ENSFCAP00000011509.6; ENSFCAG00000012406.6.
DR VGNC; VGNC:68718; ATP6V0A4.
DR eggNOG; KOG2189; Eukaryota.
DR GeneTree; ENSGT00950000182881; -.
DR HOGENOM; CLU_005230_0_2_1; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000012406; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF26; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 2.
DR PIRSF; PIRSF001293; ATP6V0A1; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 415..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 460..478
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 555..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 585..607
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 619..636
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 749..774
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 662..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 70..132
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 664..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 93412 MW; 68FB3D4D7913AECB CRC64;
MSLSPADQGC VKMASVFRSE EMCLSQLFLQ VEAAYCCVAE LGELGLVQFK DLNVNVNSFQ
RKFVNEVRRC ESLERILRFL EDEMQNEIAV QLPEKAPPTP LPREMITLET LLEKLEGELQ
EASQNQQALK KSFLELTELK HLLKKTQDFF ETETSLADDF FTEDTSGLLE LRATPAYVTG
KLGFTAGVIN RERMASFERL LWRVCRGNIY LKFSEMDVTL EDPVTKEEIK KNIFIIFYQG
EQLRQKIKKI CDGFRAIIYP CPEPAAERRE MLAGINVKLE DLITVITQTE SHRQRLLQEA
AANWHSWVIK VQKMKAIYHI LNMCNIDVTQ QCVIAEIWFP VADTGRIKRA LEQGMELSGS
SMVPILTAVQ SKTSPPTFNR TNKFTAGFQN IVDAYGVGSY REINPAPYTI ITFPFLFAVM
FGDCGHGIIM LLAALWMVLN ERRLLSQKTN NEIWNTFFHG RYLILLMGIF SIYTGLIYND
CFSKSFNIFG SSWSVRPMFR NGTWNAHVME TNPYLQLDPA IPGVYSGNPY PFGIDPIWNL
ASNKLTFLNS YKMKMSVILG IVQMVFGVVL SLFNHVYFGR TLNIVLQFIP EMIFILCLFG
YLVFMIIFKW CHFDVHMSWH APSILIHFIN MFLFNYDDPS NAPLYRHQLQ ASMIQEDATE
DIESDNSSPS MSTGQRASAG GHGAQDDHEE EFNFGDIFVH QAIHTIEYCL GCISNTASYL
RLWALSLAHA QLSEVLWTMV MNIGLRVRGW GGLIGVFIIF AIFAVLTVAI LLIMEGLSAF
LHALRLHWVE FQNKFYVGAG YKFSPFSFKY ILEGTSEE
//
