ID M3WGW7_FELCA Unreviewed; 2299 AA.
AC M3WGW7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Chondroitin sulfate proteoglycan 4 {ECO:0000313|Ensembl:ENSFCAP00000011520.5};
GN Name=CSPG4 {ECO:0000313|Ensembl:ENSFCAP00000011520.5,
GN ECO:0000313|VGNC:VGNC:61227};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011520.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011520.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011520.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011520.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011520.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011520.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011520.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR EMBL; AANG04001761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000011520; -.
DR PaxDb; 9685-ENSFCAP00000011520; -.
DR Ensembl; ENSFCAT00000012421.6; ENSFCAP00000011520.5; ENSFCAG00000012418.6.
DR VGNC; VGNC:61227; CSPG4.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000154091; -.
DR HOGENOM; CLU_000473_1_0_1; -.
DR InParanoid; M3WGW7; -.
DR OMA; PWPQGTT; -.
DR Proteomes; UP000011712; Chromosome B3.
DR Bgee; ENSFCAG00000012418; Expressed in tip of external ear and 9 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0008347; P:glial cell migration; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0097178; P:ruffle assembly; IEA:Ensembl.
DR GO; GO:0006929; P:substrate-dependent cell migration; IEA:Ensembl.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739:SF11; C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 13.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 15.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..2299
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023895564"
FT TRANSMEM 2226..2250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..194
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 204..382
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 430..525
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 555..647
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 664..766
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 785..882
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 902..993
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1022..1114
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1130..1220
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1242..1341
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1360..1453
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1477..1567
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1585..1683
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1708..1807
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1836..1928
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1945..2033
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2042..2151
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 2186..2209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2188..2203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2299 AA; 247983 MW; 14ABFB8C55567058 CRC64;
MSSGQQPPPP APALALALAL TLVMLARPSS AASFFGENHL EVPVATALTD IDLQLQFSTS
QSEALLLLAA GQADHLLLQL YSGRLQVRLT LGQEELKLQT SAGTLLSDSV LHTVQLTISD
SEALLSVDGL LNASAPVPGA PLEVPYGLFL GGTGSLGLPY VRGTSRPLRG CLHAATLNGR
NLLRPLTPDV PEGCAEEFSA DDSVALGFSG PHSLAAFPAW STRDEGTLEF TLTTRSHRAP
LAFQAGGRHG DFIYVDIFEG HLRAVVEKGQ GTVLLHNSVP VADGQPHEVS VHVDAHQLEI
SVDQYPTRTS NRGVLSYLDP RGSLLLGGLD TEASRHLQEH RLGLVPGAVN VSLLGCMEDL
SINGQRQGLR EALLTRSMAA GCRLEEDEYE DDTYGPYEAF STLAPEAWPA VELPEPCVPE
AGLPPVFANF TQLLTISPLV VAEGGTAWLE WRHVQPTLDL SEAELRKSQV LFSVSRGARH
GELELDIPGA QARKMFTLLD VVNRKARFVH DGSEDTSDQL VLEVSVTARG PVPSCLRRGQ
TYILPIQINP VNDPPRVIFP HGSLMVILEH TQKLLGPEVF QAYDPDSSCE GLTFQLLGTP
TGLPVERRDQ PGEPATEFSC RELEAGSLVY VHRGGPAQDL TFRVSDGLQA SPPATLRVVA
VRPTIQIRHN TGLHLAQGSA APVLPANLSV ETNAVGQDVS VLFRVTEAPR FGELQKQGAG
GAEGAEWRAT QAFHQRDVEQ GRVRYLSTDP QHRMEDSVEN LALEVQVGQE ILSNLSFPVT
IQRATVWLLR LEPLHTQNTQ QEALTTAHLE ATLEEEEAGP SPTTFHYEVV QAPRKGNLRL
QGTRLSDGQS FTQNDLQAGR VTYGATARAS EAVEDIFRFR VIAPPHFSPL YTFPIHIGGD
PDAPVLTNIL LSVPEGGEGI LSADHLFVKS LNSASYLYEV MERPRHGRLV WRGAQDQAAT
VTSFTNEDLL QGRLVYQHDN SETTEDDIPF VATRQSEGSG GMAWEEVRGV FRVAIQPVND
HAPVQTISRV FHVARGGRRL LTTDDVAFSD ADSGFADTQL VLTRKDLLFG SIVAVDEPTR
PIYRFTQEDL RKRRVLFVHS GADRGWIQLQ VSDGQHQATA LLEVQASEPY LHVANGSSLV
VPQGGQGTID TAVLHLDTNL DIRSGDEVRY RVTAGPHWGQ LLRAGQPATV FSQQDLLDGA
ILYSHNGSLS PRDTLAFSVE AGPVHTDATL QVTIALEGPL APLHLVRHKK IYVFQGEAAE
IRKDQLEAAQ EAVPPADIVF SVKTPPRAGY LVMLSHGASV AEPPSLDPVQ SFSQEAVDAG
RVLYLHSRPE AWSDAFSLDV SSGVGTPLEG VRVELEVLPA AIPLETQNFS VPEGGSRTLA
PPLLRVTGPY FPTLPGLDLQ VLEPPQHGAL RREEGPQEGT LGAFSWKEVE QQLILYAHDG
SETLTDSFVL VANASEMDRQ SHPVTFTITI LPVNDQPPIL TTNTGLKMWE GATVPFPPEA
LRATDSDSGP EDLVYTIERP SNGQVVLRAA PGTEVHSFTQ AQLDGGLVLF SHRGALDGGF
HFSLSDGEHA SPGHFFRVTA RKQLLLSLEG SRTLTVCPGS VQPLSSQSLR ASSSAGTDPH
HLLYRVVQGP RLGRLFHARQ GGSGEALVNF TQAEVYAGTV LYEHEMPPEP FWEVRDAVEL
QLSSPPAPDV ATTLAVAVSF EAACPQRPSR LWSNKGLWVP EGQRAEITRD ALDASNLLAT
IPSPQRPEHD VLFQITQFPT RGQLLVSGEP LDARRPHFLQ SELAAGQLVY AHGGGGTQQD
GFRFRAHLQG PAGASVSGPQ TSEAFAITVR DVNERPPRPQ ASVPLRLTRG SRAPVSRAQL
SVVDPDSAPG EIEYEVQRAP LNGFLSLAGA GPGPVIRFTQ ADVDAGRLAF VANGSSVAGI
VQLSVSDGAS PPLPVALAVD VLPAAIDVWL RAPLEVPQAL GRSTLSREQL QVVSDREEPD
AAYRLTRGPR FGQLLVAGQP ATAFSQLQVD QGEVVFAFTN FSSSRDHFSV LALARGANTS
ATVNVTVRAL LRVWAGGPWP QGATLRLDST VLDAGELANR TGSVPRFRLL AGPRHGRVVR
VPRARTEPRD SQLVEQFTQR DLEDGRLGLE VGRPEGRSPG PAGDSLTLEL WARGVPPAVA
SLDFDTEPYN AARPYSVALL SLPEAAQTEA RNPESSTPTG EPGPLASSPV PTVARRGFLG
FLEANMFSVI IPVCLVLLLL ALILPLLFYL RKRNKTGKHD VQVLTAKPRN GLASDTETFR
KVEPGQAIPL TAVPSRAQT
//
