ID M3WGY5_FELCA Unreviewed; 455 AA.
AC M3WGY5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011541.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011541.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011541.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; M3WGY5; -.
DR STRING; 9685.ENSFCAP00000011541; -.
DR Ensembl; ENSFCAT00000012446.6; ENSFCAP00000011541.6; ENSFCAG00000041710.2.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000154403; -.
DR HOGENOM; CLU_012560_8_1_1; -.
DR InParanoid; M3WGY5; -.
DR OMA; ADLRNDM; -.
DR Proteomes; UP000011712; Unplaced.
DR Bgee; ENSFCAG00000041710; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF121; KERATIN, TYPE I CYTOSKELETAL 13; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 98..410
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 407..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 102..136
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 209..247
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 354..381
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 455 AA; 49287 MW; 03394D256A3EA27B CRC64;
MSTTFLQTSS STFGGASTRG GSLWAGGGGF GGGSLYGGGG GRSISASSAR FVSSGSGGGY
GGGGMSCGFG AGVALVGVFG SGFGDFGGGD GGLLSGNEKL TMQNLNDRLA SYLDKVRALE
EANADLEVKI RDWYQKQSPS SPDREEKTVL QIPTPCLLQI LGAKIDNSRV ILEIDNARLA
ADDFRLKYEN ELALRQSVEA DTNGLRRVLD ELTLTKTDLE MQIESLNEEL AFLKKNHEEE
MKEFSSQLAG QVNVEMDAAP GVDLTRVLAE MREQYEAMAE KNRRDAEAWF FSKTEELNKE
VASNTEMIQT SKTEITDLRR TLQGLEIELQ SQLSMKAGLE SSLAETECRY ATQLQQIQGL
IGGLEAQLSE LRSEMECQDQ EYRTLLDIKT RLEQEIATYR SLLEGQDTRQ GPGCRGKPEG
GAGWGWGGES SGDSIRINVE ETVDGKVVSS HKREV
//
