ID M3WHL1_FELCA Unreviewed; 731 AA.
AC M3WHL1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Striatin {ECO:0000313|Ensembl:ENSFCAP00000011853.6};
GN Name=STRN {ECO:0000313|Ensembl:ENSFCAP00000011853.6,
GN ECO:0000313|VGNC:VGNC:81230};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000011853.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000011853.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011853.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000011853.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011853.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000011853.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000011853.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat striatin family.
CC {ECO:0000256|ARBA:ARBA00009616}.
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DR EMBL; AANG04003404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WHL1; -.
DR Ensembl; ENSFCAT00000012787.6; ENSFCAP00000011853.6; ENSFCAG00000012784.6.
DR VGNC; VGNC:81230; STRN.
DR eggNOG; KOG0642; Eukaryota.
DR GeneTree; ENSGT00950000183095; -.
DR HOGENOM; CLU_009108_2_0_1; -.
DR Proteomes; UP000011712; Chromosome A3.
DR Bgee; ENSFCAG00000012784; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013258; Striatin_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15653; STRIATIN; 1.
DR PANTHER; PTHR15653:SF2; STRIATIN; 1.
DR Pfam; PF08232; Striatin; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 37..164
FT /note="Striatin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08232"
FT REPEAT 410..451
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 463..495
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 516..557
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 653..694
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 111..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 55..103
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 731 AA; 80703 MW; 6E3B2E09ABE1EE08 CRC64;
MDEQAGPGVF FSNNHPGAGG AKGLGPLAGA ARAQYSLPGI LHFLQHEWAR FEVERAQWEV
ERAELQAQIA FLQGERKGQE NLKKDLVRRI KMLEYALKQE RAKYHKLKYG TELNQGDMKP
PSYDSDEGNE TEVQPQQNSQ LMWKQGRQLL RQYLQEVGYT DTILDVKSKR VRALLGFSSD
VTDREDDRNQ DSVINGTEAE VKETAMIGKS ELTDSASVLD NFKFLESAAA DFSDEDEDDD
IDGREKSIID TSTIVRKKAL PDSSEDRDTK EALKEFDFLV TSEEGDSESR SAGDGTEWGP
NRSKLQDMLA NLRDVDELPS LQPSVGSPSR PTSSRLPEHE INRADEVEAL TFPPSSGKSF
IMGADEALES ELGLGELAGL TVANEADSLT YDIANNKDAL RKTWNPKFTL RSHFDGIRAL
AFHPTEPVLI TASEDHTLKM WNLQKTAPAK KSTSLDVEPI YTFRAHKGPV LCVVLSSSGE
QCYSGGADGL IQGWNTTNPN VDPYDSYDPS VLRGPLLGHT DAVWGLAYSA AHQRLLSCSA
DGTLRLWNTA EAAPALSVFN DNQELGIPAS VDLVSSDPSH MVASFSKGYT SIFNMETQQR
ILTLESNLDT TATSSCQINR VISHPTLPIS ITAHEDRHIK FYDNNTGKLI HSMVAHLEAV
TSLAVDPNGL YLMSGSHDCS IRLWNLESKT CIQEFTAHRK KFEESIHDVA FHPSKCYIAS
AGADALAKVF V
//
