ID M3WHY1_FELCA Unreviewed; 763 AA.
AC M3WHY1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Transcription factor RFX3 {ECO:0000256|ARBA:ARBA00040859};
DE AltName: Full=Regulatory factor X 3 {ECO:0000256|ARBA:ARBA00042137};
GN Name=RFX3 {ECO:0000313|Ensembl:ENSFCAP00000012012.6,
GN ECO:0000313|VGNC:VGNC:69305};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000012012.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000012012.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012012.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000012012.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012012.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000012012.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000012012.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AANG04003917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006939112.1; XM_006939050.2.
DR AlphaFoldDB; M3WHY1; -.
DR Ensembl; ENSFCAT00000012954.6; ENSFCAP00000012012.6; ENSFCAG00000012950.6.
DR VGNC; VGNC:69305; RFX3.
DR eggNOG; KOG3712; Eukaryota.
DR GeneTree; ENSGT01050000244879; -.
DR HOGENOM; CLU_010393_1_1_1; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000012950; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR PANTHER; PTHR12619:SF20; TRANSCRIPTION FACTOR RFX3; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 197..272
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 678..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 85047 MW; A717096956F62FCB CRC64;
MMAHSTGNIS LETIMQTSET GSDTGSTVTL QTSVASQAAV PTQVVQQVPV QQQVQQVQTV
QQVQHVYPAQ VQYVEGSDTV YTNGAIRTTT YPYTETQMYS QNTGGNYFDT QGSSAQVTTV
VSSHSMVGTG GIQMGVTGGQ LISSSGGTYL IGNSMENSGH SVTHTTRASP ATIEMAIETL
QKSDGLSTHR SSLLNSHLQW LLDNYETAEG VSLPRSTLYN HYLRHCQEHK LDPVNAASFG
KLIRSIFMGL RTRRLGTRGN SKYHYYGIRV KPDSPLNRLQ EDMQYMAMRQ QPMQQKQRYK
PMQKVDGVAD GFTGSGQQTG TSVEQTVIAQ SQHHQQFLDA SRALPEFGEV EISSLPDGTT
FEDIKSLQSL YREHCEAILD VVVNLQFSLI EKLWQTFWRY SPSTPTDGTT ITESSNLSEI
ESRLPKAKLI TLCKHESILK WMCNCDHGMY QALVEILIPD VLRPIPSALT QAIRNFAKSL
EGWLSNAMNN IPQRMIQTKV AAVSAFAQTL RRYTSLNHLA QAARAVLQNT SQINQMLNDL
NRVDFANVQE QASWVCQCDD SMVQRLETDF KMTLQQQSTL EQWAAWLDNV MMQALKPYEG
RPSFPKAARQ FLLKWSFYSS MVIRDLTLRS AASFGSFHLI RLLYDEYMFY LVEHRVAQAT
GETPIAVMGE FGDLNAVSPG NLDKDEGSEV ESEMDEELDD SSEPQAKREK TELNQAFQVG
CMQPVLESGV QPSLLNPIHS EHIVTSSQTI RQCSATGNTY TAV
//
