ID M3WKC5_FELCA Unreviewed; 1122 AA.
AC M3WKC5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=MCF.2 cell line derived transforming sequence like {ECO:0000313|Ensembl:ENSFCAP00000013215.6};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSFCAP00000013215.6,
GN ECO:0000313|VGNC:VGNC:63411};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013215.6, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000013215.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013215.6,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000013215.6, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013215.6,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000013215.6}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013215.6};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AANG04001781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WKC5; -.
DR Ensembl; ENSFCAT00000014246.6; ENSFCAP00000013215.6; ENSFCAG00000014242.6.
DR VGNC; VGNC:63411; MCF2L.
DR eggNOG; KOG4240; Eukaryota.
DR GeneTree; ENSGT00940000157874; -.
DR HOGENOM; CLU_007130_1_0_1; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000014242; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 20..192
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 599..779
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 797..913
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1023..1083
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 523..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 125972 MW; 980B54B36116FFA9 CRC64;
MTLSRISLLS QDISGLWLLL KTSTDEIMHQ DITPLCAADI QDQLKKRFAY LSGGRGQDGS
PVITFPDYPA FSDVPDKEFQ NVMTYLTSIP SLQDAGIGFI LVIDRRQDKW TSVKASVLRI
AASFPANLQL VLVLRPAGFF QRTLSDLAFK FNRDDFKMKV PVIMLSSVPE LHGYIDKSQL
TEDLGGTLDY CHTRWLCHRT AIESFALMVK QTAQMLQSFG TELAETELPN DVQSTSSVLC
AHTEKKDKAK EDMRAALDEG QSLLQSVREP LAKGGGRSLS QDQLDNQTTV QRLLAQLNET
EAAFDEFWAK HQQKLQQCLQ LRHFEQDFRE VKASLDALAQ KIATFTDVGN SLAHAGHLLK
DLTSFEEKSS VSVERALALA LEGEKLIDSR HYAVDSIRPK CHELQHLCNQ FAAEVERRRE
LLSKSLELHS LLEASMKWCD EGIYLLASQP VDKCQSQEGA EAALQEIEKF LETGAENKIQ
ELDRIYQDYE SVLTTDLMEH VQKVYQKQEG TEEMFHRRQA SLKKLAAKQT RPVQPVAPRP
EALTKSPCPS PGSRRGSENS PEGSMLRRGP YRRAKSEVTE SRQGRGSSTG DEEESLAILR
RHVMNELLDT ERVYVEELLC VLEGYAAELD NPLMAHLVSP GLQNKKDILF GNMEEIYHFH
NRIFLRELEN YTDCPELVGR CFLERMEEFQ IYEKYCQNKP RSESLWRQCS DCPFFQECQR
KLDHKLSLDS YLLKPVQRIT KYQLLLKEML KYSKSCEGAE DLQEALSSIL GILKAVNDSM
HLIAITGYDG NLSDLGRLLM QGSFSVWTDH KKGHTKVKDL ARFKPMQRHL FLHEKAVLFC
KKREENGEGY EKAPSYSYKQ SLNMAAVGIT ENVKGDVRKF EIWYNAREEV YIIQAPTVEI
KAAWVSEIRK VLTSQLQACR EASQHRALEQ SQSLPLPTPP STSPSKGNTR NIKKLEERKT
DPLSLEGYVS STPLPKPPEK GRGWSKTSHP SEAPEDDGWS SAEELINSSD AEEEGRVGPR
KLVPGKYTVV LGDEKESPEA LAVRSGDVVE VVQEGDEGLW YVRNLTSSKE SWVPASSLST
LLGTSGSAQC LSSSESSAGS ALLSASSSCS ESCGAPLSDL QG
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