ID M3WKI7_FELCA Unreviewed; 906 AA.
AC M3WKI7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=Adhesion G protein-coupled receptor D1 {ECO:0000313|Ensembl:ENSFCAP00000013299.4};
GN Name=ADGRD1 {ECO:0000313|Ensembl:ENSFCAP00000013299.4,
GN ECO:0000313|VGNC:VGNC:80420};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013299.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000013299.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013299.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000013299.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013299.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000013299.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013299.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; AANG04002765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019669966.1; XM_019814407.1.
DR AlphaFoldDB; M3WKI7; -.
DR STRING; 9685.ENSFCAP00000013299; -.
DR PaxDb; 9685-ENSFCAP00000013299; -.
DR Ensembl; ENSFCAT00000014339.6; ENSFCAP00000013299.4; ENSFCAG00000014334.6.
DR GeneID; 101080410; -.
DR CTD; 283383; -.
DR VGNC; VGNC:80420; ADGRD1.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000159783; -.
DR HOGENOM; CLU_008509_0_0_1; -.
DR InParanoid; M3WKI7; -.
DR OMA; PANTVMP; -.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000014334; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT DOMAIN 598..842
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 886..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 99880 MW; 5B7BAFC9D1D37EB6 CRC64;
MRKLLCLCWG HPWLLLFYCD FQVRGVYSRS VAHPGFEVLA SASHYWPLET VDGIHELQDT
TGVLRTHNLT VLPSHNSTFV RTNDSAYSNF SATVDIMEGK VSKGVYLREE KGVTLLYYGQ
YNTSCISNPA KCDPDGVTFS FFWKTHGEQS RPIPSAYGGQ VISEGFKVCS SGGKGSVELY
TRENAKTWEA TFSPPGPYWT HVLFTWKSKE GLKVYVNGTL STSDPSGKVS HAYGEPSVNL
VIGSEQDQTK RYEVGAFDEF IIWERALTPD EIAMYFTAAV GKHALLSSTP PSFFMTPPAN
TVLPTNAYHP IITNLMEKRK NLQSPGTVLS YLRNVSLNLP NKPLSQETAL NLTKAFLKTM
GEVLQLPSWI DVSEDNAVVL GLIETVDTVM GHISSNVQAS DPQVTIIGSS SMAEFSVAKL
LPEAINSSHY RFPAQGQSYI QVPHEAFRSQ AWTTIVGLLY HTMHNYLDNI WPAKTKIAEA
ANYKTHPLSA ASYLISLEVS PPPTLSQNLS GSPLVTVQLR HRLSRRQRSE ATNSSNQVFL
YCAFLDFSSG EGVWSNQGCV LAEGNLSYSV CRCTHLTNFA ILMQVVPLEL TQGQQVALSS
ISYIGCSLSV VCLVLTLVTF AMLSSVSTIR NQRYHIHANL SFAVLVAQIL LLISFSFKPG
TVPCQVLAVL LHYFFLSAFA WMLVEGLHLY SMVIKVFGSE DSKHLYYYGI GWGFPLVICI
ISISFAMNSY GTNNNCWLSI TSGAVWAFVA PALSIIVVNV GILVAVTRVI SQISADNYKI
HGDPSAFKLT AKAVAVLLPI LGTSWVFGVL AVNSQAMVFQ YMFAVLNSLQ GFFIFLFHCL
LNSEVRAAFK HKTKVWTLTS SSNRNTNAKP FGSDIMNGTR PGTVSTRLSP WDKSSQSAHR
VDLSTV
//
