ID M3WML8_FELCA Unreviewed; 583 AA.
AC M3WML8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=SHC adaptor protein 2 {ECO:0000313|Ensembl:ENSFCAP00000014316.4};
GN Name=SHC2 {ECO:0000313|Ensembl:ENSFCAP00000014316.4,
GN ECO:0000313|VGNC:VGNC:65118};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000014316.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000014316.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014316.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000014316.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014316.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000014316.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000014316.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WML8; -.
DR STRING; 9685.ENSFCAP00000014316; -.
DR PaxDb; 9685-ENSFCAP00000014316; -.
DR Ensembl; ENSFCAT00000015442.5; ENSFCAP00000014316.4; ENSFCAG00000015438.5.
DR VGNC; VGNC:65118; SHC2.
DR eggNOG; KOG3697; Eukaryota.
DR GeneTree; ENSGT00950000182870; -.
DR HOGENOM; CLU_029532_0_0_1; -.
DR InParanoid; M3WML8; -.
DR OMA; GDEWSRK; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000015438; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF5; SHC-TRANSFORMING PROTEIN 2; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 146..328
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 488..579
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..23
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 62513 MW; 9CF9956B67F96D8C CRC64;
MTQGPGGRTP PAPPAPPEPE APTTFCALLP RMPQWKFAAP AGFLGRGPAA ARAAGGAGAA
DSQPEPAGPA SVPALAAAVL GACEPRCAAP CPLPALSRCR AAGGRGPRGA RGAAGPADAS
ADEWIRKGSF IHKPAHGWLH PDARVLGPGV SYIVRYMGCI EVLRSMRSLD FNTRTQVTRE
AINRLHEAVP GIRGSWKKKA PNKALASILG KTNLRFAGMS IAVSISTDGL NLSVPATRQV
IANHHMQSIS FASGGDTDMT DYVAYVAKDP INQRACHILE CCEGLAQSII STVGQAFELR
FKQYLHSPPR VVLPPERLTR PEESAWGDEE ETEHNYYNSI PGKEPPLGGL VDSRLALTQP
CAVGALGQGV SPARRDTRSL PWDLGPSGNS PPGDGYVQAD ARGPRDYEDH LYVNTQGLDA
PEPLQPEDSP KKDLFDMRPF EDALKLHECS AGAGAAVAPL PLEDQWPSPP TRRAPIAPTE
EQLRQEPWYH GQMSRRAAEK LLRADGDFLV RDSVTNPGQY VLTGMHAGQP KHLLLVDPEG
VVRTKDVLFE SISHLIDYHL QNGQPIVAAE SELHLRGVVK REP
//