ID M3WPC9_FELCA Unreviewed; 1100 AA.
AC M3WPC9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN Name=GUCY2D {ECO:0000313|Ensembl:ENSFCAP00000016017.4,
GN ECO:0000313|VGNC:VGNC:67517};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000016017.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000016017.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016017.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000016017.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016017.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000016017.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000016017.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; AANG04000740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WPC9; -.
DR STRING; 9685.ENSFCAP00000016017; -.
DR PaxDb; 9685-ENSFCAP00000016017; -.
DR Ensembl; ENSFCAT00000019015.5; ENSFCAP00000016017.4; ENSFCAG00000018062.5.
DR VGNC; VGNC:67517; GUCY2D.
DR eggNOG; KOG1023; Eukaryota.
DR GeneTree; ENSGT00940000161326; -.
DR InParanoid; M3WPC9; -.
DR OMA; LPFDTIH; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000018062; Expressed in eyeball of camera-type eye and 6 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0042622; C:photoreceptor outer segment membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF228; RETINAL GUANYLYL CYCLASE 1; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 520..803
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 875..1005
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 812..839
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1100 AA; 118856 MW; AE9185F0D1C9025C CRC64;
MTACALPAGG CPDPRRRAPA RRVPSPPGVP RALPLLLLLL PPSARPAVFT VGVLGPWACD
PIFARARPDL AARLAAARLN HNPAMAGSPR FEVALLPEPC RTPGSLGAVS SALGRVSGLV
GPVNPAACRP AELLAQEAGV TLVPWGCPGT RAAGTTAPAV TPAADALYAL LRAFRWARVA
LVTAPQDLWV EAGRALSAAL RARGLPVALV TTMEPSDVSG AREALRRVQD GPRVRAVIMV
MHSVLLGGQE QRCLLEAAEE LGLADGSLVF LPFDTLHYAL SPGPEALAAL ANSSRLRRAH
DAVLTLTRHC PPGGSVMDSL RRAQERQELP SDLDLLQVSP LFGTIYDAVF LLAGGVARAR
AAAGGGWVSA AAVARHIQDA QVPGFCGALG GAEEPPFVLL DTDAAGDQLF ATYLLDPTRG
SLRSAGTPVH FPRGGGGPGP DPSCWFEPDI ICNGGLEPGL VFIGFLLVVG MGLTGAFLAH
YVRHRLIHIQ MVSGPNKIIL TLDDITFLHP QGGSSRKVVQ GSRSSLGAHS VSDVRSVPSQ
PADSANVGLY EGDWVWLKKF PGDQHIAIRP ATRTAFSKLQ ELRHENVVLY LGLFLGSGAG
GTMAPGERML AVVSEHCTRG SLHDLLAQRD IKLDWMFKSS LLLDLIKGMR YLHHRGVAHG
RLKSRNCVVD GRFVLKVTDH GQGRLLEAQR VLPEPPSAED QLWTAPELLR DPALERRGTM
AGDVFSLGII MQEVVCRSAP YAMLELTAEE VVERVRSPPP LCRPSVSVDQ APTECIQLMK
QCWAEQPDLR PSMDRTFEQF KSINKGRKTN IIDSMLRMLE QYSSNLEDLI RERTEELELE
KQKTDRLLTQ MLPPSVAEAL KTGTPVEPEY FEEVTLYFSD IVGFTTISAM SEPIEVVDLL
NDLYTLFDAI IGSHDVYKVE TIGDAYMVAS GLPQRNGQRH AAEIANMALD ILSAVGSFRM
RHMPEVPVRI RIGLHSGPCV AGVVGLTMPR YCLFGDTVNT ASRMESTGLP YRIHVNISTV
QILRALDEGF QTEVRGRTEL KGKGAEDTYW LVGRRGFNKP IPKPPDLQPG ASNHGISLQE
IPLERRLKLE KARPGQFSGK
//
