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Database: UniProt
Entry: M3WRT5_FELCA
LinkDB: M3WRT5_FELCA
Original site: M3WRT5_FELCA 
ID   M3WRT5_FELCA            Unreviewed;       998 AA.
AC   M3WRT5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   30-AUG-2017, entry version 38.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 6 {ECO:0000313|Ensembl:ENSFCAP00000017070};
GN   Name=KCNH6 {ECO:0000313|Ensembl:ENSFCAP00000017070};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017070, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000017070, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017070,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000017070}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017070};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000017070}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017070};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000017070}.
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DR   EMBL; AANG02052061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000017070; -.
DR   Ensembl; ENSFCAT00000031591; ENSFCAP00000017070; ENSFCAG00000024807.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00760000118772; -.
DR   InParanoid; M3WRT5; -.
DR   OMA; MFVVDIV; -.
DR   OrthoDB; EOG091G024C; -.
DR   Proteomes; UP000011712; Chromosome E1.
DR   Bgee; ENSFCAG00000024807; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR   InterPro; IPR030172; KCNH6.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF579; PTHR10217:SF579; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01470; ERGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|SAAS:SAAS00091826};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00807593};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00807732};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00807568};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00807693}.
FT   TRANSMEM    261    282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    398    422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    515       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      594    694       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   998 AA;  110460 MW;  174D1F3314B43A47 CRC64;
     MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE LFGYSRVEVM
     QRPCTCDFLT GPNTPRSAMS RLAQALLGTE ECKVDILYYR KDASSFRCLV DVVPVKNEDG
     AVIMFILNFE DLAQLLAKSE RRSLSQCLLS QSFLGSEGSH GRPGAQGPGT GRVKYRTISQ
     IPQFTLNFVE FNLEKHRSGS TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ
     APRIHRGTLL HYSPFKAVWD WLILLLVIYT AIFTPYSAAF LLSDQDESQR MDCGYTCSPL
     TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAIH YFKGWFLIDM VAAIPFDLLI
     FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV LFLLMCTFAL IAHWLACIWY
     AIGNVERPYL EPKIGWLDSL GAQLGKHYNG SDPASGPSVQ DKYVTALYFT FSSLTSVGFG
     NVSPNTNSEK VFSICVMLIG SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ
     IPNPLRQRLE EYFQHAWSYT NSIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFRGASK
     GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI LGKNDIFGEP
     ISLHARPGKS SADVRALTYC DLHKIQRADL LEVLDMYPAF ADSFWSKLEV TFNLRDAGGG
     LQSSPQPAPG SQDHQGFFLS DNQSASPPSP KLGFQPPSQG YSLLEPGSLT SVGTGPCTPG
     HSAAAPSLSI SDASGLWPEL LHQMPPRPRD SPPNPQGDPD CWPRELGSRL EQLQAQMNRL
     ESRMSSDLSR ILQLLQQPLP QGHTGYILGA PTSNDLALFP VASTTQSPGT RLPQGGLPPA
     QVPGCGDLNK CRLKRKNSSS GVPPLVMATD KILTLSLEQE QPEGLLSPLA SPLHPLEVQG
     LICGPRFPSL PERLGPVPKQ LEFQRHGSDP GLARSWGK
//
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