ID M3WSM0_FELCA Unreviewed; 684 AA.
AC M3WSM0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=SKI like proto-onco {ECO:0000313|Ensembl:ENSFCAP00000017356.2};
GN Name=SKIL {ECO:0000313|Ensembl:ENSFCAP00000017356.2,
GN ECO:0000313|VGNC:VGNC:65171};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017356.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017356.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017356.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017356.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017356.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017356.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017356.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR EMBL; AANG04001816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019666005.1; XM_019810446.1.
DR AlphaFoldDB; M3WSM0; -.
DR PaxDb; 9685-ENSFCAP00000017356; -.
DR Ensembl; ENSFCAT00000030339.4; ENSFCAP00000017356.2; ENSFCAG00000031064.4.
DR VGNC; VGNC:65171; SKIL.
DR eggNOG; ENOG502QT5P; Eukaryota.
DR GeneTree; ENSGT00940000158435; -.
DR HOGENOM; CLU_025786_0_0_1; -.
DR OrthoDB; 5400889at2759; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000031064; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR CDD; cd21084; DHD_Sno; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.10.260.20; Ski; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR PANTHER; PTHR10005:SF3; SKI-LIKE PROTEIN; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 261..356
FT /note="c-SKI SMAD4-binding"
FT /evidence="ECO:0000259|SMART:SM01046"
FT REGION 417..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 538..674
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 429..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 77505 MW; 7B08FAE593E792FC CRC64;
MENLQTNFSL VQGSNKKLNG MGDDCGPPVK KMMTDVPANG KMMINKMPTV KKEHLEDYEV
PMETDGEHVK RTCASVPEPL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR YSQESMSPTV
FLPLPSPQVL PGPLFIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFSL
QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP
QNGSVLPAKN SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRNG
KRTQSKIDTS SGMELQSWYP VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS
QSKEVTKTET SRTVPRPSEK PHSSGKHQKV VSYPDVSLEE QEKMDLKTSK ELCSRVDPSV
SNNSTSKKKP ESTTCNFIRD TSKTGTDRDI VASSPLLVKD IICEDDKGKI MEEVMRTYVK
QQEKLNSILQ KKQQLQMEVE MLSSSKAMKE LTEEQQNLQK ELESLQNEHA QRMEEFYIEQ
KDLEKKLEQV MKQKCTCDSN LEKDKEAEYA AQLAELRQRL DHAEADRQEL QDELRQEREA
RQKLEMMIKE LKLQILKSSK TAKE
//
