ID M3WTE8_FELCA Unreviewed; 395 AA.
AC M3WTE8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Threonine aldolase 1 {ECO:0000313|Ensembl:ENSFCAP00000017634.2};
GN Name=THA1 {ECO:0000313|Ensembl:ENSFCAP00000017634.2,
GN ECO:0000313|VGNC:VGNC:109225};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017634.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017634.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017634.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017634.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017634.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017634.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017634.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; AANG04004184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003997292.1; XM_003997243.4.
DR AlphaFoldDB; M3WTE8; -.
DR STRING; 9685.ENSFCAP00000017634; -.
DR PaxDb; 9685-ENSFCAP00000017634; -.
DR Ensembl; ENSFCAT00000022428.4; ENSFCAP00000017634.2; ENSFCAG00000024226.4.
DR VGNC; VGNC:109225; THA1.
DR eggNOG; KOG1368; Eukaryota.
DR GeneTree; ENSGT00390000014681; -.
DR HOGENOM; CLU_029381_0_1_1; -.
DR InParanoid; M3WTE8; -.
DR OMA; MIDFRSD; -.
DR OrthoDB; 178754at2759; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000024226; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008732; F:L-allo-threonine aldolase activity; IBA:GO_Central.
DR GO; GO:0006545; P:glycine biosynthetic process; IBA:GO_Central.
DR GO; GO:0006567; P:threonine catabolic process; IBA:GO_Central.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 33..323
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 233
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ SEQUENCE 395 AA; 42335 MW; B7ABFC739AE7B3FB CRC64;
MLRGLARAAV QRQGALRTRG SGGGAGVPVH VVDLRSDTVT KPGPAMRRAM AEAVVGDDDY
GEDPTVRELQ EKAATLLGVD RTLFVPTNTM ANLISVMCHC QRRGSQLLLG QESHLHVYEQ
GGVAQIAGVH SHPLPDLPHG TLDLAELERM VTRGLGSPYH PVCELICLEN THSSSGGRVL
PIDYLRQVRL LAQSCGVRVH LDGARLMNAA VALHVPPARI VEHCDSVSLC FSKGLGAPVG
ALVGGPKDFI EGAWRLRKAL GGGMRQAGVL AAAALVGLAD VEEVLLRDHQ NARRFAQGLQ
ELASPICSVD LAAVETNMVM VTVDGLPPQE LCRRLQAVSA DEVAQTGRAV RVLLFPWTGR
SVRAVWHRDV SARDTELALR KWGFVLKQLG ALRTG
//
