ID M3WTS0_FELCA Unreviewed; 634 AA.
AC M3WTS0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Zinc finger SWIM-type containing 2 {ECO:0000313|Ensembl:ENSFCAP00000017756.2};
GN Name=ZSWIM2 {ECO:0000313|Ensembl:ENSFCAP00000017756.2,
GN ECO:0000313|VGNC:VGNC:67384};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017756.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017756.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017756.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017756.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017756.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017756.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017756.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WTS0; -.
DR STRING; 9685.ENSFCAP00000017756; -.
DR PaxDb; 9685-ENSFCAP00000017756; -.
DR Ensembl; ENSFCAT00000024405.4; ENSFCAP00000017756.2; ENSFCAG00000022504.4.
DR VGNC; VGNC:67384; ZSWIM2.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00390000006826; -.
DR HOGENOM; CLU_029121_0_0_1; -.
DR InParanoid; M3WTS0; -.
DR OMA; RNQKWRS; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000022504; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR CDD; cd16486; mRING-H2-C3H2C2D_ZSWM2; 1.
DR CDD; cd16494; RING-CH-C4HC3_ZSWM2; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR007527; Znf_SWIM.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR InterPro; IPR039903; Zswim2.
DR PANTHER; PTHR21540:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2; 1.
DR PANTHER; PTHR21540; RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF04434; SWIM; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00184; RING; 2.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS50089; ZF_RING_2; 2.
DR PROSITE; PS50966; ZF_SWIM; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 54..87
FT /note="SWIM-type"
FT /evidence="ECO:0000259|PROSITE:PS50966"
FT DOMAIN 147..199
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 230..281
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 345..386
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 634 AA; 72983 MW; 0F467F7CB88144D1 CRC64;
MLRRGCKASE RRRHLSNHLS GQQDLALSGS IYLLREIGPT GFLLREEEPE NRDFRVFLGN
PHVCNCSTFL KGGELCKHIC WVLLKKFKLP RNHECALQLG LVEREISDLL RGIHRVQTPQ
QGTNDETVHI EEDGYIKQKE IGSDDICSIC QEVLLEKKRP VTFCRFGCGN SLHIKCMKIL
ANYQDMISNA SMLKCPLCRK EFAPIKLILE EFKNSSKLVT AAEKERLDKH LGIPCNNCKQ
FPIEGICYKC TECIEYHLCQ ECFDSCCHLS HPFTFREKRN QRWRSLENRS DETVKYVDIK
NETEEKMPHF QGKQGQVYTP KQVVKSLPLL LITKTSKLLA PGYQCRLCLK AFCLGQHTRL
LPCAHKFHRK CIDSWLLYKC NSCPIDGQVI YNPLIWKDTA VNGHTHQSIS NTNITHLSKQ
EEPELFIPGT GLVLKQNRLE ILPSIPQHDS EKLNTPESPT DTYQNITIDD LFSIKLDDSN
SRRLIYEYKI SQHFPKYLQD SLTEHIGKMS SQAFLPSITN KNIICLTAME SPCISEKWHT
SQSQKMAKDC KHINHNPKKT LGTRIKDKKR SNTSLQEDLN LIVSWGTSKL SLSKRYSNYM
RKVRQKCNLS RRPVSHPLNT KSTELSLILE GVQL
//
