ID M3WUC4_FELCA Unreviewed; 510 AA.
AC M3WUC4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Polyamine oxidase {ECO:0000313|Ensembl:ENSFCAP00000017961.4};
GN Name=PAOX {ECO:0000313|Ensembl:ENSFCAP00000017961.4};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017961.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017961.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017961.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017961.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017961.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017961.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017961.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|ARBA:ARBA00005995}.
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DR EMBL; AANG04003988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WUC4; -.
DR STRING; 9685.ENSFCAP00000017961; -.
DR PaxDb; 9685-ENSFCAP00000017961; -.
DR Ensembl; ENSFCAT00000031941.4; ENSFCAP00000017961.4; ENSFCAG00000022153.4.
DR eggNOG; KOG0685; Eukaryota.
DR GeneTree; ENSGT00940000158274; -.
DR HOGENOM; CLU_004498_2_0_1; -.
DR InParanoid; M3WUC4; -.
DR OMA; LEPGNRW; -.
DR OrthoDB; 2642916at2759; -.
DR Proteomes; UP000011712; Chromosome D2.
DR Bgee; ENSFCAG00000022153; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0046592; F:polyamine oxidase activity; IBA:GO_Central.
DR GO; GO:1901307; P:positive regulation of spermidine biosynthetic process; IEA:Ensembl.
DR GO; GO:0009446; P:putrescine biosynthetic process; IEA:Ensembl.
DR GO; GO:0009447; P:putrescine catabolic process; IEA:Ensembl.
DR GO; GO:0046203; P:spermidine catabolic process; IEA:Ensembl.
DR GO; GO:0046208; P:spermine catabolic process; IEA:Ensembl.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF405; PEROXISOMAL N(1)-ACETYL-SPERMINE_SPERMIDINE OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 24..496
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 510 AA; 55663 MW; DEFB586E64AC7E37 CRC64;
MESSGGRAEA PGRGPRVLVV GGGIAGLGAA QRLCSHPAFR RLRVLEATSR AGGRICSERS
FGGVVELGAH WIHGPSQGNP VFQLAARYQL LEEKDLSEEN QLIETGGHVG LPSVSYTSSG
VSVSHELVVE MAGLFYGLID QTREFLHLPD APVPSVGEYL KREISQHAAG WTEDEETRKL
KLAILNSFFN VECCVSGTHS MDLVALAPFG EYTVLPGLDC TFPGGYQGLT NRIMASLPED
VVVFNKPVKT IHWNGSFREA SSPGETCPVL VECEDGGCFP AHHVIVTVPL GFLKECLDTF
FEPPLPTQKA EAIRKIGFGT NNKIFLEFEE PFWEPDCQFI QVVWEDTSPL QDGASELQHV
WFKKLIGFLV LPSFESAHVL CGFIAGLESE FMETLSDEEV LLSLTQVLRR VTGNAELPAP
RSVLRSRWHS APYTRGSYSY VAVGSSGDDV DLLAQPLPAD GAEAQVLFAG EATHRAFYST
THGALLSGWR EADRLIALWD TQAQLPEPRL
//
