ID M3WUD8_FELCA Unreviewed; 370 AA.
AC M3WUD8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Platelet-derived growth factor D {ECO:0000256|ARBA:ARBA00018876};
GN Name=PDGFD {ECO:0000313|Ensembl:ENSFCAP00000017975.3,
GN ECO:0000313|VGNC:VGNC:64082};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000017975.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000017975.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017975.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000017975.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017975.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000017975.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017975.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers,
CC and with heterodimers formed by PDGFRA and PDGFRB.
CC {ECO:0000256|ARBA:ARBA00026039}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; AANG04000690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WUD8; -.
DR Ensembl; ENSFCAT00000032159.4; ENSFCAP00000017975.3; ENSFCAG00000024385.4.
DR VGNC; VGNC:64082; PDGFD.
DR eggNOG; ENOG502QPQY; Eukaryota.
DR GeneTree; ENSGT00940000159575; -.
DR HOGENOM; CLU_037859_1_0_1; -.
DR OMA; HHETCEC; -.
DR OrthoDB; 3908391at2759; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000024385; Expressed in eyeball of camera-type eye and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF4; PLATELET-DERIVED GROWTH FACTOR D; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00042; CUB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 52..170
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 259..362
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 370 AA; 42402 MW; A3DD1ED3CCE29488 CRC64;
MRPLGLVYTL VCANLCGCRD APAAPQSASL RALRAAGLRR DDSNHLTDLY RRDETIQVTG
NGHVQSPRFP NSYPRNLLLT WRLRSQEKTR IQLAFDSQFG LEEAENDICR YDFVEVEDVS
ETSTVIRGRW CGHKDAPPRI TSRTNQIKIT FKSDDYFVAK PGFKIYYSFV EDFQPAAASE
TNWESVTSSI SGVSYHSPSV TDPTLTADAL DKTVAEFDTV EDLLKHFNPE SWREDLENLY
LETPHYRGRS YHDRKSKVDL DRLNDEVKRY SCTPRNYSVN LREELKLTNV VFFPRCLLVQ
RCGGNCGCGT VSWKSCSCNS GKTVKKYHEV LQFEPGHFRR RARAKHMALV DIQLDHHERC
DCVCSSRPPR
//
