ID M3WWB8_FELCA Unreviewed; 286 AA.
AC M3WWB8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 24-JAN-2024, entry version 71.
DE SubName: Full=Hydroxysteroid 17-beta dehydrogenase 12 {ECO:0000313|Ensembl:ENSFCAP00000018656.3};
GN Name=HSD17B12 {ECO:0000313|VGNC:VGNC:62847};
GN Synonyms=ALKBH3 {ECO:0000313|Ensembl:ENSFCAP00000018656.3};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000018656.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000018656.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018656.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000018656.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018656.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000018656.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000018656.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
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DR EMBL; AANG04004363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006937275.1; XM_006937213.2.
DR AlphaFoldDB; M3WWB8; -.
DR SMR; M3WWB8; -.
DR PaxDb; 9685-ENSFCAP00000018656; -.
DR Ensembl; ENSFCAT00000026617.4; ENSFCAP00000018656.3; ENSFCAG00000022122.4.
DR GeneID; 101082850; -.
DR KEGG; fca:101082850; -.
DR CTD; 221120; -.
DR VGNC; VGNC:62847; HSD17B12.
DR eggNOG; ENOG502QW9E; Eukaryota.
DR GeneTree; ENSGT00940000154860; -.
DR HOGENOM; CLU_048788_2_1_1; -.
DR OrthoDB; 36492at2759; -.
DR Proteomes; UP000011712; Chromosome D1.
DR Bgee; ENSFCAG00000022122; Expressed in tip of external ear and 10 other cell types or tissues.
DR GO; GO:0051213; F:dioxygenase activity; IEA:InterPro.
DR GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IEA:InterPro.
DR GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IEA:InterPro.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032854; ALKBH3.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR31212; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR PANTHER; PTHR31212:SF4; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 172..278
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 33309 MW; C949A6E4990A6BFC CRC64;
MEDKRRRARV QGAWAGPAKS QATAQPATTA KSHLHQRPGQ TWTKKEHHLL DRQFVFREPQ
EVVRRAPEPR VIDREGVYDI SVSPTGVSRV CLYPGFVDLK EADWVLEQLC EVVPWKQRTG
VREDVTYKQP RLTAWYGELP YTYSRITMEP NAHWHPVLLT LKDQIEKNTG HTFNSLLCNL
YRNEKDSVDW HSDDEPSLGR CPIIASLSFG ATRTFEMRRK PPPEENGDYT YVERVKIPLD
HGTLLIMEGA TQADWQHRVP KEYHSREPRI NLTFRTVYPD PRGARW
//
