ID M3WZ14_FELCA Unreviewed; 417 AA.
AC M3WZ14;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Osteoclast-stimulating factor 1 {ECO:0000256|ARBA:ARBA00040640};
GN Name=OSTF1 {ECO:0000313|Ensembl:ENSFCAP00000019604.3,
GN ECO:0000313|VGNC:VGNC:102960};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019604.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000019604.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019604.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000019604.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019604.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000019604.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019604.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Induces bone resorption, acting probably through a signaling
CC cascade which results in the secretion of factor(s) enhancing
CC osteoclast formation and activity. {ECO:0000256|ARBA:ARBA00037432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04003917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WZ14; -.
DR STRING; 9685.ENSFCAP00000019604; -.
DR PaxDb; 9685-ENSFCAP00000019604; -.
DR Ensembl; ENSFCAT00000031022.4; ENSFCAP00000019604.3; ENSFCAG00000022374.4.
DR VGNC; VGNC:102960; OSTF1.
DR eggNOG; ENOG502QTZB; Eukaryota.
DR GeneTree; ENSGT00920000149159; -.
DR HOGENOM; CLU_092255_0_0_1; -.
DR InParanoid; M3WZ14; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000022374; Expressed in spleen and 11 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd11772; SH3_OSTF1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24155; OSTEOCLAST-STIMULATING FACTOR 1; 1.
DR PANTHER; PTHR24155:SF10; OSTEOCLAST-STIMULATING FACTOR 1; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 215..274
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REPEAT 342..374
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 45213 MW; 3650A292E3713AE5 CRC64;
MPLLPRSYPV GGGPGSSRQP RALSHSGRTR RRLQPRRGGA GRGGAGLRRP GPRARVRPRK
VRPFLIGGAR SRASPGASLR RPPLAPARSA AARAAARAAR APAASELPVR EPISARRPDG
GHFLVARPRA REARAAAGRG GARRRAALTA FASPTAKGGR RSLKAHRRTA DKKKLWGPRS
AGWRGVRLAF RAWSRGSAAP GSAMSKPPPK PVKPGQVKVF RALYTFEPRT PDELYFEEGD
IIYITDMSDT NWWKGTSKGK TGLIPSNYVA EQAESIDNPL HEAAKRGNLS WLRECLDNRV
GVNGLDKAGS TALYWACHGG HKDIVEMLFT QPNIELNQQN KLGDTALHAA AWKGYADIVH
LLLEKGARTD LRNNEKKLAL DMATNAACAS LLKKKQGTDA VRTLSNAEEY LDDEDSD
//
