GenomeNet

Database: UniProt
Entry: M3WZI5_FELCA
LinkDB: M3WZI5_FELCA
Original site: M3WZI5_FELCA 
ID   M3WZI5_FELCA            Unreviewed;       462 AA.
AC   M3WZI5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Pepsinogen B2 {ECO:0000313|Ensembl:ENSFCAP00000019776.3};
GN   Name=PGB2 {ECO:0000313|VGNC:VGNC:82032};
GN   Synonyms=OVGP1 {ECO:0000313|Ensembl:ENSFCAP00000019776.3};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019776.3, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000019776.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019776.3,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000019776.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019776.3,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000019776.3}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019776.3};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AANG04003279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3WZI5; -.
DR   Ensembl; ENSFCAT00000031644.4; ENSFCAP00000019776.3; ENSFCAG00000040956.2.
DR   VGNC; VGNC:82032; PGB2.
DR   eggNOG; KOG1339; Eukaryota.
DR   GeneTree; ENSGT00940000162223; -.
DR   HOGENOM; CLU_013253_3_0_1; -.
DR   Proteomes; UP000011712; Chromosome C1.
DR   Bgee; ENSFCAG00000040956; Expressed in testis and 4 other cell types or tissues.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.60; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF70; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT   DOMAIN          146..459
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        350
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        177..182
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   462 AA;  51077 MW;  3E8A59769BF9D51B CRC64;
     MNKSSKQLMK CSFWEGSWTS SASCLTTFME AGKSSQDTIV PCSLCLETPN LRFAPSSRKR
     RSAGLTISMS HTPTRGMCGL AMMMSSASVT RIILKKGKSI RQVMEERGVL QTFLKNHPKV
     DPAAKYLFNN DAVAYEPFTN YLNSYYFGEI SIGTPPQNFL VLFDTGSSNL WVPSTYCKSQ
     ACSNHNTFNP SMSSTYQNNG QTYTLYYGSG SLTVLLGYDT VTVQNIVIHN QEFGLSEIEP
     SNPFYYANFD GILGMAYPNL AVGNSPTVME SMMQQGQLTS PIFSFYFSRQ PTYQYGGELI
     LGGVDTQFYS GEIVWTPVTR ELYWQIAIDE FLIGNQATGF CSQGCQGIVD TGTFPLTVPQ
     QYLDSFVKAT GAQQDQNGDF VVNCNSIQSM PTITFVISGS PLPLPPSTYV LNNNGYCTLG
     IEVTYLPSPN GQPLWILGDV FLREYYTVYD MAVNRVGFAL SA
//
DBGET integrated database retrieval system