ID M3WZI5_FELCA Unreviewed; 462 AA.
AC M3WZI5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Pepsinogen B2 {ECO:0000313|Ensembl:ENSFCAP00000019776.3};
GN Name=PGB2 {ECO:0000313|VGNC:VGNC:82032};
GN Synonyms=OVGP1 {ECO:0000313|Ensembl:ENSFCAP00000019776.3};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000019776.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000019776.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019776.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000019776.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019776.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000019776.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000019776.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04003279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3WZI5; -.
DR Ensembl; ENSFCAT00000031644.4; ENSFCAP00000019776.3; ENSFCAG00000040956.2.
DR VGNC; VGNC:82032; PGB2.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000162223; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000040956; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF70; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 146..459
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 164
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 350
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 177..182
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 462 AA; 51077 MW; 3E8A59769BF9D51B CRC64;
MNKSSKQLMK CSFWEGSWTS SASCLTTFME AGKSSQDTIV PCSLCLETPN LRFAPSSRKR
RSAGLTISMS HTPTRGMCGL AMMMSSASVT RIILKKGKSI RQVMEERGVL QTFLKNHPKV
DPAAKYLFNN DAVAYEPFTN YLNSYYFGEI SIGTPPQNFL VLFDTGSSNL WVPSTYCKSQ
ACSNHNTFNP SMSSTYQNNG QTYTLYYGSG SLTVLLGYDT VTVQNIVIHN QEFGLSEIEP
SNPFYYANFD GILGMAYPNL AVGNSPTVME SMMQQGQLTS PIFSFYFSRQ PTYQYGGELI
LGGVDTQFYS GEIVWTPVTR ELYWQIAIDE FLIGNQATGF CSQGCQGIVD TGTFPLTVPQ
QYLDSFVKAT GAQQDQNGDF VVNCNSIQSM PTITFVISGS PLPLPPSTYV LNNNGYCTLG
IEVTYLPSPN GQPLWILGDV FLREYYTVYD MAVNRVGFAL SA
//