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Database: UniProt
Entry: M3X680_FELCA
LinkDB: M3X680_FELCA
Original site: M3X680_FELCA 
ID   M3X680_FELCA            Unreviewed;      2005 AA.
AC   M3X680;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSFCAP00000022132};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000022132, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000022132, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022132,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000022132}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022132};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000022132}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000022132};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000022132}.
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DR   EMBL; AANG02198535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG02198542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000022132; -.
DR   Ensembl; ENSFCAT00000029888; ENSFCAP00000022132; ENSFCAG00000024761.
DR   eggNOG; ENOG410KCTY; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3X680; -.
DR   OMA; EGCIKKF; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C1.
DR   Bgee; ENSFCAG00000024761; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    256    276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    432       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    766    784       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    796    819       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    876    904       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    966    989       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1212   1230       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1251   1273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1299       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1328   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1449   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1587   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1753   1776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    439       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      512    715       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      766    994       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1003   1205       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1210   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1786       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      429    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2005 AA;  227014 MW;  56EC696F524C3B4A CRC64;
     MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAQKPKRE QDNDDENKPK PNSDLEAGKN
     LPFIYGDIPP EMVSEPLEDL DPYYISKKTF IVLNKGKAIF RFSATSALYI LTPLNPVRKI
     AIKILVHSYP FHSTLFSMLI MCTILTNCVF MTLSNPPDWT KNVEYTFTGI YTFESLIKIL
     ARGFCLEDFT FLRDPWNWLD FSVIVMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPGLK
     TIVGALIQSV KKLSDVMILT VFCLSVFALI GLQLFMGNLR NKCLQWPPSD SAFETNTTSY
     FNGTMDSNGI FVNVTMSTFN WKDYIEDDSH FYVLDGQKDP LLCGNGSDAG QCPEGYICVK
     AGRNPNYGYT SFDTFSWAFL SLFRLMTQDY WENLYQLTLR AAGKTYMIFV LVIFLGSFYL
     VNLILAVVAM AYEEQNQATL EEAEQKEAEF QQMLEQLKKQ QEEAQAVAAA SAASRDFSGI
     GGLGELLESS SEASKLSSKS AKEWRNRRKK RRQREHLEGN NKGEGDRFPK SESEDSVKRR
     SFLFSMDGNR LTSDKKFYSP HQSLLSIRGS LFSPRRNSKT SIFSFRGRAK DVGSENDFAD
     DEHSTFEDSE SRRDSLFVPH RHGERRNSNV SQASMSSRMV PGLPANGKMH STVDCNGVVS
     LVGGPSALTS PTGQLLPEGT TTETEVRKRR LSSYQISMEM LEDSSGRQRA MSIASILTNT
     MEELEESRQK CPPCWYRFAN VFLIWDCCDA WLKVKHLVNL IVMDPFVDLA ITICIVLNTL
     FMAMEHYPMT GQFSSVLTVG NLVFTGIFTA EMVLKIIAMD PYYYFQEGWN IFDGIIVSLS
     LMELGLANVE GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI
     FAVVGMQLFG KSYKECVCKI SSDCQLPRWH MNDFFHSFLI VFRVLCGEWI ETMWDCMEVA
     GQTMCLIVFM LVMVIGNLVV LNLFLALLLS SFSSDNLAAT DDDNEMNNLQ IAVGRMQKGI
     DYVKSKIREC FRKTFFRKPK VIEVHEGNKI DSCISNNTGI EISKELNYLK DGNGTTSGVG
     TGSSVEKYVI DENDYMSFIN NPSLTVTVPI AVGESDFENL NTEEFSSESE LEEKKHKLNA
     TSSSEGSTVD VAPPREGEQA EMEPEEDLKP EACFTEGCIK KFPFCQVSIE EGKGKVWWNL
     RKTCYSIVEH NWFETFIVFM ILLSSGALAF EDIYIEQRKT IKTMLEYADK VFTYIFILEM
     LLKWVAYGFQ TYFTNAWCWL DFLIVDVSLV SLVANALGYS ELGAIKSLRT LRALRPLRAL
     SRFEGMRVVV NALVGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYHCV NTTTGNMFEV
     SEVNNLSDCQ ALGKQARWKN VKVNFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRDVKLQ
     PVYEENLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFNLRNLFE IPELPSKHNI
     IILGSCTNQR XPIPRPANKF QGMVFDFVTR QVFDISIMIL ICLNMVTMMV ETDDQSKYMT
     LVLSRINLVF IILFTGEFVL KLVSLRYYYF TIGWNIFDFV VVILSIVGMF LAELIEKYFV
     SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS
     NFAYVKKEAG IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSAPPD CDPDTIHPGS
     SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL SEDDFEMFYE
     VWEKFDPDAT QFIEFSKLSD FAAALDPPLL IAKPNKVQLI AMDLPMVSGD RIHCLDILFA
     FTKRVLGESG EMDALRIQME DRFMASNPSK VSYEPITTTL KRKQEEVSAA IIQRNFRCYL
     LRQRLKKVSS EYNKEAIKGR IDLPIKEDMI IDKLNGNSTP EKTDGSSSTT SPPSYDSVTK
     PDKEKFEKDK PEKESKGKEV RETQK
//
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