ID M3X9E9_FELCA Unreviewed; 272 AA.
AC M3X9E9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=TGFB induced factor homeobox 1 {ECO:0000313|Ensembl:ENSFCAP00000023251.1};
GN Name=TGIF1 {ECO:0000313|Ensembl:ENSFCAP00000023251.1,
GN ECO:0000313|VGNC:VGNC:66139};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023251.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000023251.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023251.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000023251.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023251.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000023251.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023251.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; AANG04003548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003995085.1; XM_003995036.3.
DR AlphaFoldDB; M3X9E9; -.
DR STRING; 9685.ENSFCAP00000023251; -.
DR PaxDb; 9685-ENSFCAP00000023251; -.
DR Ensembl; ENSFCAT00000023857.4; ENSFCAP00000023251.1; ENSFCAG00000029898.4.
DR GeneID; 101084747; -.
DR KEGG; fca:101084747; -.
DR CTD; 7050; -.
DR VGNC; VGNC:66139; TGIF1.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000155230; -.
DR HOGENOM; CLU_034318_2_0_1; -.
DR InParanoid; M3X9E9; -.
DR OMA; FPLCQSV; -.
DR OrthoDB; 3180467at2759; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000029898; Expressed in uterus and 10 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR PANTHER; PTHR11850:SF59; HOMEOBOX PROTEIN TGIF1; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 33..96
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 35..97
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 29589 MW; 686F0412384C2527 CRC64;
MKSKKGVVVA SGSETEDDDN MDIPLDLSSS AGGAKRRRRG NLPKESVQIL RDWLYEHRYN
AYPSEQEKAL LSQQTHLSTL QVCNWFINAR RRLLPDMLRK DGKDPNQFTI SRRGAKISEA
SSVESAMGIK NFIPALEESP FHSCSAGPNP ALGRPLSPKS SSPGSILARP SVICHTTVTA
LKDVPFSLCQ PVGVGQNTDI QQIAASSFTD TSLMYPEDTC KSGPSTNTQS GLFNTPPPTP
PDLNQDFSGF QLLVDVALKR AAEMELQAKL TA
//
