ID M3XAR4_FELCA Unreviewed; 829 AA.
AC M3XAR4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Cullin 1 {ECO:0000313|Ensembl:ENSFCAP00000023718.3};
GN Name=CUL1 {ECO:0000313|Ensembl:ENSFCAP00000023718.3,
GN ECO:0000313|VGNC:VGNC:61282};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023718.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000023718.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023718.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000023718.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023718.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000023718.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023718.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AANG04000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XAR4; -.
DR STRING; 9685.ENSFCAP00000023718; -.
DR Ensembl; ENSFCAT00000028043.4; ENSFCAP00000023718.3; ENSFCAG00000008615.6.
DR VGNC; VGNC:61282; CUL1.
DR eggNOG; KOG2166; Eukaryota.
DR GeneTree; ENSGT00940000154774; -.
DR HOGENOM; CLU_004747_6_1_1; -.
DR InParanoid; M3XAR4; -.
DR OMA; IREWDRY; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000008615; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0160072; F:ubiquitin ligase complex scaffold activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 426..653
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 829 AA; 94569 MW; 243CDFD622960A6A CRC64;
MCGRGCRLLN STGGCPATAH LTTALLGTTK TWTSTKVIVR RVHQQENGGL IVRSKLHVYN
YCTSVHQSNQ ARGAGVPPSK SKKGQTPGGA QFVGLELYKR LKEFLKNYLT NLLKDGEDLM
DESVLKFYTQ QWEDYRFSSK VLNGICAYLN RHWVRRECDE GRKGIYEIYS LALVTWRDCL
FRPLNKQVTN AVLKLIEKER NGETINTRLI SGVVQSYVEL GLNEDDAFAK GPTLTVYKES
FESQFLADTE RFYTRESTEF LQQNPVTEYM KKAEARLLEE QRRVQVYLHE STQDELARKC
EQVLIEKHLE IFHTEFQNLL DADKNEDLGR MYNLVSRIQD GLGELKKLLE THIHNQGLAA
IEKCGEAALN DPKMYVQTVL DVHKKYNALV MSAFNNDAGF VAALDKACGR FINNNAVTKM
AQSSSKSPEL LARYCDSLLK KSSKNPEEAE LEDTLNQVMV VFKYIEDKDV FQKFYAKMLA
KRLVHQNSAS DDAEASMISK LKQACGFEYT SKLQRMFQDI GVSKDLNEQF KKHLTNSEPL
DLDFSIQVLS SGSWPFQQSC TFALPSELER SYQRFTAFYA SRHSGRKLTW LYQLSKGELV
TNCFKNRYTL QASTFQMAIL LQYNTEDAYA VQQLTDSTQI KMDILAQVLQ ILLKSKLLVL
EDENANVDEV ELKPDTLIKL YLGYKNKKLR VNINVPMKTE QKQEQETTHK NIEEDRKLLI
QAAIVRIMKM RKVLKHQQLL GEVLTQLSSR FKPRVPVIKV QEPHGRSCPC VVLGEQGVTK
MRPTAVGISI RTRFLQKEMG LSLKPFIGGA WVAQSVKRPT SARSRSCGP
//
