ID M3XB85_FELCA Unreviewed; 276 AA.
AC M3XB85;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=FA core complex associated protein 24 {ECO:0000313|Ensembl:ENSFCAP00000023889.4};
GN Name=FAAP24 {ECO:0000313|Ensembl:ENSFCAP00000023889.4,
GN ECO:0000313|VGNC:VGNC:62033};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023889.4, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000023889.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023889.4,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000023889.4, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023889.4,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000023889.4}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023889.4};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04004361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XB85; -.
DR STRING; 9685.ENSFCAP00000023889; -.
DR PaxDb; 9685-ENSFCAP00000023889; -.
DR Ensembl; ENSFCAT00000026740.4; ENSFCAP00000023889.4; ENSFCAG00000022497.4.
DR VGNC; VGNC:62033; FAAP24.
DR eggNOG; KOG2841; Eukaryota.
DR GeneTree; ENSGT00390000009456; -.
DR HOGENOM; CLU_111628_0_0_1; -.
DR InParanoid; M3XB85; -.
DR OMA; GPVHVPF; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000022497; Expressed in spleen and 11 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0071821; C:FANCM-MHF complex; IEA:Ensembl.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR CDD; cd20076; XPF_nuclease_FAAP24; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR026985; FAAP24.
DR InterPro; IPR040646; PND.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR31786; FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24; 1.
DR PANTHER; PTHR31786:SF2; FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF17949; PND; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 73..196
FT /note="Fanconi anemia core complex-associated protein 24
FT pseudonuclease"
FT /evidence="ECO:0000259|Pfam:PF17949"
FT DOMAIN 227..275
FT /note="DisA/LigA helix-hairpin-helix motif"
FT /evidence="ECO:0000259|Pfam:PF12826"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 276 AA; 30442 MW; 6E3C758EB3CDF90C CRC64;
MKNWSAHRRE PGSGAQQVKV PDPLAVVEVG SSWARPPPRT GLRSHHPDGA GVSGPSRSRQ
PMARNAPEGT GPMHVPFGHI VANTKWRGSK LLQGMQGKIK IVFEDGLTPV DFYVSSRSCI
LYVTEADLVA GNGYRKRLVQ VRNSSNLQGI VIVEKTQMSE QYFSAIQKFT VLDLGMVLLP
VTSQMEASCL IIQLVQEQTK EPSKNPFLSK KRTRMPELSL LRTVQQIPGV GKVKAPLLLQ
KFPSIQQLSN ASIRELEPVV GQAVAQHIHA FFTQPR
//
