ID   M3XDH3_FELCA            Unreviewed;      1026 AA.
AC   M3XDH3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 3.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Klotho beta {ECO:0000313|Ensembl:ENSFCAP00000024679.3};
GN   Name=KLB {ECO:0000313|Ensembl:ENSFCAP00000024679.3,
GN   ECO:0000313|VGNC:VGNC:63126};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000024679.3, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000024679.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024679.3,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000024679.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024679.3,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000024679.3}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000024679.3};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3XDH3; -.
DR   STRING; 9685.ENSFCAP00000024679; -.
DR   PaxDb; 9685-ENSFCAP00000024679; -.
DR   Ensembl; ENSFCAT00000028814.4; ENSFCAP00000024679.3; ENSFCAG00000026771.4.
DR   VGNC; VGNC:63126; KLB.
DR   eggNOG; KOG0626; Eukaryota.
DR   GeneTree; ENSGT00940000157489; -.
DR   HOGENOM; CLU_001859_5_2_1; -.
DR   InParanoid; M3XDH3; -.
DR   OMA; ARMKVTH; -.
DR   Proteomes; UP000011712; Chromosome B1.
DR   Bgee; ENSFCAG00000026771; Expressed in liver and 8 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017134; F:fibroblast growth factor binding; IEA:Ensembl.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:Ensembl.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR   Gene3D; 3.20.20.80; Glycosidases; 2.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353:SF68; BETA-KLOTHO; 1.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 2.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        986..1006
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1026 AA;  118240 MW;  9CFB4C45E79AC42A CRC64;
     MNGFFFSTDE RNIHYRKTMC NRGLQRSAIL SAFILLRAVT GFSGDGRAVW SKNPHFSPVN
     ESQLFLYDTF PKNFLWGVGT GAFQVEGNWK TDGKGPSIWD HFIQTHLKNV NGTDSSSDSY
     IFLEKDLSAL DFIGVSFYQF SISWPRLFPD GIAAVANAKG LQYYNALLDA LVLRNIQPIV
     TLYHWDLPLA LQEKYGGWKN ETIIDIFNDY ATYCFQTFGD RVKYWITIHN PYLVAWHGYG
     TGLHAPGEKG NLAAVYSVGH NLIKAHSKVW HNYNVNFRPH QKGWLSITLG SHWIEPNRSE
     DMMDILKCQQ SMVSVLGWFA NPIHGDGDYP EVMKKKLLSI LPLFSEAEKS EVRGTADFFA
     FSFGPNNFKP QNTMAKMGQN VSLNLREVLN WIKLEYGNPR ILIAENGWFT DSHVKTEDTT
     AIYMMKNFLN QVLQAIRFDE IQVFGYTAWS LLDGFEWQDA YTTRRGLFYV DFNSKQKERR
     PKSSAHYYKQ IVQENGFTLK ESTPDVQGQF PCDFSWGVTE SVLKPKAVAS SPQFSDPHLY
     VWNVTGNRLL HRVEGVRLKT RPAQCTDFVS IKRQLEMLAR MKVTHYRFAL DWPSILPAGN
     LSVVNRQALR YYRCVVSEGL KLNISPMVTL YYPTHAHLGL PTPLLHSGGW LNPSTVQAFQ
     DYAGLCFQEL GDLVRLWITI NEPNRLSDIY SHTSNDTYRA AHNLLIAHAL VWHLYDRRYR
     SAQHGAVSLS LHSDWAEPAN PYADSHWQAA ERFLQFEIAW FAEPLFKTGD YPLAMREYIA
     FKNRQGLSRS ALPRFTEEER RLVKGAADFY ALNHFTTWFV MHARQNGSRY DADRDVQFLQ
     DITCLSSPSR LAVLPWGERK VLRWIQKNYG DVDVYITANG IDDQSLENDE LRKYYLEKYI
     QEALKAQLID KVKIKGYYAF KLTEEKSKPR FGFFTSEFKA KSSVQLYNKL ISNSGFPSDI
     TSPRCSQTPR NTECIVCLFL VQKKPLIFFG CCFFSTLVLL LSITIFHKRK RKKNWKAKNL
     QHIPLK
//