ID M3XIK7_LATCH Unreviewed; 2629 AA.
AC M3XIK7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Filamin A {ECO:0000313|Ensembl:ENSLACP00000022563.1};
GN Name=FLNA {ECO:0000313|Ensembl:ENSLACP00000022563.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022563.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000022563.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; AFYH01214753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01214762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006010193.1; XM_006010131.2.
DR Ensembl; ENSLACT00000026169.1; ENSLACP00000022563.1; ENSLACG00000002404.2.
DR GeneID; 102345455; -.
DR CTD; 2316; -.
DR GeneTree; ENSGT00940000153588; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002404; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21308; CH_FLNA_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF5; FILAMIN-A; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 36..142
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 159..262
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 269..367
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 369..467
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 468..564
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 565..657
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 661..757
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 758..860
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 861..959
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 960..1055
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1056..1148
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1149..1243
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1244..1343
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1344..1436
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1437..1532
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1533..1629
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1630..1725
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1784..1842
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1842..1934
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1932..2021
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2024..2116
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2114..2212
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2215..2307
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2309..2402
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2406..2498
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2534..2628
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2629 AA; 280213 MW; 223F645256A4E295 CRC64;
MSSSHQRLNQ SVVTADKDAE MPSTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVNKRIANL
QADLSDGLRL IALLEVLSQK KMYRKYNQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK
AIVDGNLKLI LGLIWTLILH YSISMPMWDE EEDEEVKKQT PKQRLLGWIQ NKLPEIPITN
FNRDWQTGRA LGALVDSCAP GLCPDWDSWD QSKPVDNARE AMQQADDWLG VPQVIAPEEI
VDPNVDEHSV MTYLSQFPKA KLKPGAPLRP KLNPKKARAY GPGVEPTGNV VMKRAAFTVE
TISAGQGEVL VYVEDPAGHK EEAKVTANND KNRTYSVYYI PKVTGNHKVT VLFAGQHISK
SPFEVNVGKA MGDASKVTAQ GPGLEASGNI ANKMTYFEVY TAGAGVGGVD VIVTDPKGGK
DTANVQVEDK GNSTYRCTYT PTMEGVYTVY ITFAEVQIPK SPFTVNIGQA CNPSACRAVG
RGLQPKGVRV KETADFKVYT KGAGSGELKV TIKGPKGIEE AVKRKDLGDG VYAFDYYPTS
SGSYTVTITW GGHNIPRSPF EVKVGTEAGQ QKVRAWGPGL EGGVVGKSAD FVVEAIGGDV
GTLGFSVEGP SQAKIECDDK GDGSCDVRYW PTEAGEYAVH VLCNNEDIKY SPFMADIVPA
PKDFYPDKVQ AYGPGLEKTG LAINKPAEFT VNAKSAGKAP LKIYAQDGEG NPIDVMVKNN
GNGTYTCSYL PKKPVKHTVM VSWGGVNIPN SPFRVNVGAG THPNKVKVYG PGVAKTGLKA
HEPTYFTVDC AEAGQGDVSI GIKCAPGVVG PAEADIPFDI IRNDNDTFTV KYNPPGAGSY
TIMVLFADQA TPMSPFRIKV DPSHDASKVK AEGPGLTRTG VEMAKPTHFT VNTKPAGKAK
LDVQFTGPTK GEAVRDFDII DNHDSSYTVK YTPLQQGNLG VGVTYGGDHI PKSPFSVGVA
PSLDLSKIKV SGLGDKMEVG KDQEFTVKSK GAGGQGKVAA KITGPSYKTV PCKVEPGLSA
DNSVVKFIPR EEGPYQVDLT YDGVPVPGSP FPVEGVAPTD PTKVKAYGPG LKGGVVRTSC
PFTIDTKGAG MGGLGLTVEG PCEAKIECLD NGDGTCSVNY LPTEPGDYNI NILFAEKHIP
GSPFKADIKP CFDPSKVKCS GPGLERATVG QAGKFNVDCS NAGSAELTIE IISDNGMEAE
VHIQDNGDGT YTITYIPLYP GVYTITIKYG GQMVPNFPSK LQVEPAIDAS GVKVYGPGVE
GKGVFREATT EFSVDARALT KAGGPHIKSR VSNPSGSLTD SYIQDNGDGT YKVEYTPYEE
GVHSVDVSYD GTPVPNSPFR VPVTEGCDPS RVRVFGPGLM GGITNKPNKF FVETRGAGTG
GLGLAVEGPS EAKMSCTDNK DGSCSVEYVP YEPGTYSLNV TYGGKQVPGS PFQVPVGDVV
DPSKVKCTGP GVGNAVRANI PQSFTVDTSK AGAAPLQVSV LGPKGVVEPV EVTDNGDGTK
RVSYVPTREG PYTVSVLYGD EEIPRSPFKV KVLPTHDASK VKASGPGLNT TGVPASLPVE
FTIDAKDAGE GLLAVQITDP EGKPKKANIR DNQDGTYTVS YVPDMTGRYT ILIKYGGDEI
PYSPYRIRAL PTGDASKCTV TGAGIGPTIQ IGEETLITVD AKAAGKGKVT CTVCTPDGTE
VDVDVAENED GTFDIYYTAQ QPGKYVICVR FGGEHIPNSP FQVMALDGEQ IVPQPMVQQQ
LAPQYAYPPG VQQPWATDRA RMNGLDVAGL RPFDLVIPFT IKKGEITGDV RMPSGKVAKP
DITDNKDGTV TVKYAPTEAG LHEMDIKYDG MHIPGSPLQF YVDYVNSGDV TAYGPGLIHG
MVNKPAVFTV NTKDAGEGGL SLAIEGPSKA DISCTDNQDG TCTVSYLPVL PGDYNILVKY
NEKHIAGSPF TAKITGDDSM RMSHLKVGSA ADIPLDIAES DLSQLTASVT TPSGREEPCL
LKRLRNGHIG ISFVPKEIGE HVVSIKKNGR HIPSSPITVM ISQSEIGDAS RVRVSGPGLS
EGRTFEPAEF IIDTREAGYG GLSLSIEGPS KVDISTEDLE DGTCKVTYCP TEPGNYIINI
KFADQHVPGS SFAVKVTGEG RVKELITRRR RAASVANVGS QCDLNLKIPE INLEDMTAQV
TSPSGILHDA EIMEGDDNTY CIRFVPTEMG VHTVSVKYKS QHVPGSPFQF TVGPLGEGGS
HKVRAGGPGL ERAEAGVPAE FSIWTREAGA GGLSIAVEGP SKAEISFEDR KDGSCGVSYI
VQEPGDYEVS IKFNDDHIPD SPFIVPVASP SDDARRLTVA SLQESGLKVN QPASFAVSLN
GAKGVIDAKV HSPSGALEEC CVTEIDEDKY AVRFIPREYG IYSIDVKFNG SHIPGSPFKI
RVGEPGQAGD PGMVSAYGPG LEGGTTGSPA DFIVNTTNAG PGALAVTIDG PSKVKMDCQE
CAEGYKVNYT PMAPGNYLIS IKYGGPYHVA GSPFKARVTG PHLVSSHSLH ETSSVFVDSI
AKSDAVVQHG AMPKYTSDAS KVVAKGLGLN KAFVGQKNSF TVDCSKAGNN MLLVGVHGPK
IPCEEIVVKH LGSKLYNVMY LLKEKGDYIL VVKWGEDHIP GSPFSVSVP
//
