ID M3XK54_LATCH Unreviewed; 559 AA.
AC M3XK54;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO2B1 {ECO:0000313|Ensembl:ENSLACP00000023110.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000023110.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000023110.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR EMBL; AFYH01179116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01179125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XK54; -.
DR Ensembl; ENSLACT00000025454.1; ENSLACP00000023110.1; ENSLACG00000006268.2.
DR GeneTree; ENSGT01080000257336; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd17460; MFS_SLCO2B_OATP2B; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF87; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 164..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 201..229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 249..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 330..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 365..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 518..536
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 441..496
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 559 AA; 60501 MW; E68719CEF9E6066A CRC64;
MTVASTVKSN QHHETRRKCS GSPFHSIKFF VVCHGVLQLS QLLVSGYLKS SVSTIEKRFG
LSSKTSGMIT SSNEIGNTLL IVFVSYFGSR VHRPRFIGCG AVLVCLAGFL MSLPHFIVGP
YEFDNSIASS FNNATDTCWA NRSSRAHGLV PTCGAGKVQE DSRVLFLLFS SQILLGIGGV
PIQPFGISYV DDFASASNSP LYLGILFAIT ILGPGLAFML GSVMLKFYVD IDKFSSDEIV
LEAGDPRWVG AWWLGFLIAS SIVAVSAVPY FFFPRKMPKE TVNCERLEMK DKTEMLAGCK
VTSDALRSLT LLEFIKKFPH ILLRTLKNPI YLIVVMGQVN LSAMVAGLAT FMAKFMERQF
TITASFANLL IGGLIIPAAV MGVVVGGVIM KRLQLTVKQL GVMCSIALFC CLCVAAPLLF
IGCATQKVAG ITHHYNSSEK LKLSSQCNSL CFCEPEAFNP VCGSDGVEYI SPCYAGCKVV
NVEPLEKKVL NYTECSCIST TGTEGLASPG TCGSSCSHLL KTFVILVSVI AFVASLSQTP
SFMMVLSMDA WACPVRHCH
//
