ID M3XM72_MUSPF Unreviewed; 1062 AA.
AC M3XM72;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSMPUP00000000172.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSMPUP00000000172.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000172.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000000172.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
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DR EMBL; AEYP01014359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01014361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XM72; -.
DR STRING; 9669.ENSMPUP00000000172; -.
DR Ensembl; ENSMPUT00000000176.1; ENSMPUP00000000172.1; ENSMPUG00000000175.1.
DR eggNOG; KOG3531; Eukaryota.
DR GeneTree; ENSGT00940000158642; -.
DR HOGENOM; CLU_012301_0_0_1; -.
DR InParanoid; M3XM72; -.
DR OMA; HKHMPED; -.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0022405; P:hair cycle process; IEA:Ensembl.
DR GO; GO:0016322; P:neuron remodeling; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0071800; P:podosome assembly; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0033623; P:regulation of integrin activation; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1062
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004043515"
FT DOMAIN 68..348
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 560..751
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 780..877
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 953..1050
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 416..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 665..692
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 416..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 120960 MW; 43F8CBA6F95FB8A9 CRC64;
MTLWGFLLCF KGFSWWRMGE IEGTYRVLQT PGTRLGSPTP TGVSTLEPGQ TLSVTAARAS
ARMQEKHLHI RVKLLDNTVE IFDIEPKRDG QMLLTQVWRR LNLTECDYFG LEFQHPRSYW
IWLEPMKPII RQVRRPKNAL LRLAVKFFPP DPGQLQEEYT RYLFALQLKR DLLEERLPCT
DTTAALLASH LLQAEIGDYD ETLDREHLKA NEYLPSQEHS LEKILEFHRK HTGQTPAESD
FQVLEIARKL EMYGIRFHTA SDREGARINL AVSHMGVLVF QGTTKINTFN WSRVRKLSFK
RKRFLIKLHP EVRGPYQDTL EFLLGSRDEC KNFWKICVEY HTFFRLLDQP KAKAKAVFFS
RGSSFRYSGR TQKQLVDYVR DSGVKRVPYE RRHSKTRMSI RALTADLPRQ SISFTEGLRT
SASPSSTNVS FYSVPTSPLA PRGPPDFKDS SSSLTEPQAP DAKRPAAERS SGAAADGDTR
WAQSPGPPAL QPCQGLSMES PQPSPTTRKS PLSLSPASQV TLGPAGQSLS PLLSPVLSHV
GGARTDNEEQ PKHKSMAADE AYFIAKEILA TERTYLKDLE VLTVWFRSAV VKEDAMPADL
MTLLFSNIDP IYEFHRGFLR EVEQRLALWE GSSDTHVPGG HQRIGDILLR NMHQLKGFTS
CFQRHDEVLT ELEKATKRLK KLEAVYREFE LQKVCYLPLN AFLLKPIQRL LHYRLLLGRL
CTHYGPAHPD HADCHDALQA ITEVTSTLQH SLARLENLQK LTELQRDLVG IENLITPGRE
FIREGCLHKL TKKGLQQRMF FLFSDMLLYT SKGVTGSSHF RIRGRLPLHG MLVEEGEHER
PVPHCFTICA AQKTVVVAAS TRLEKEKWIC DLNTAIDAAK SRSGQSLVLP GSVVCMPPSR
CMEEVSPEQE SEDARSSRGS LEGQGQPRAN TTVRVCWYRN TSVSRADHSA AVENQLSGYL
LRKFKNSNGW QKLWVVFTNF CLFFYKTHQD DYPLASLPLL GYSVSVPKEA DGVHKEHVFK
LQFKSHVYFF RAESKYTFGR WMEVIERAGS SPGRARRPEE EA
//
