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Database: UniProt
Entry: M3XNL7_MUSPF
LinkDB: M3XNL7_MUSPF
Original site: M3XNL7_MUSPF 
ID   M3XNL7_MUSPF            Unreviewed;      1924 AA.
AC   M3XNL7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSMPUP00000000667};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000667, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000000667}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000000667};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000000667}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000000667}.
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DR   EMBL; AEYP01014806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000000667; -.
DR   Ensembl; ENSMPUT00000000679; ENSMPUP00000000667; ENSMPUG00000000669.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3XNL7; -.
DR   OMA; EGCIKKF; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    159    180       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    186    206       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    336    363       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    697    715       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    727    750       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    807    835       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    897    920       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1143   1161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1182   1204       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1230       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1259   1285       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1380   1404       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1463   1481       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1493   1511       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1518   1543       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1580   1608       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1672   1695       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       88    370       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      443    646       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      697    925       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      934   1136       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1141   1412       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1462   1705       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      360    401       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1924 AA;  218962 MW;  9AD76DB9458DEA7C CRC64;
     MCRMKRWHRH CWYPRGLKAS AFLLENLLLL LKNVLQKRKP KSPRENKTMM MRTNQSQIVT
     WKLGRTFHLF TETFLQRWCQ SPWRTWTRTI SIRKYTFTGI YTFESLIKIL ARGFCLEDFT
     FLRDPWNWLD FSVIVMAYVT EFVDLGNVSA LRTFRVLRAL KTISVIPGLK TIVGALIQSV
     KKLSDVMILT VFCLSVFALI GLQLFMGNLR NKCLQWPPSD SAFETNTTSY FNGTMDSNGI
     FVNITMSTFN WKDYIEDDSH FYVLDGQKDP LLCGNGSDAG QCPEGYICVK AGRNPNYGYT
     SFDTFSWAFL SLFRLMTQDY WENLYQLTLR AAGKTYMIFF VLVIFLGSFY LVNLILAVVA
     MAYEEQNQAT LEEAEQKEAE FQQMLEQLKK QQEEAQAVAA ASAASRDFSG IGGLGELLES
     SSEASKLSSK SAKEWRNRRK KRRQREHFEG NNKGEGDRFP KSESEDSVKR RSFLFSMDGN
     RLTSDKKFYS PHQSLLSIRG SLFSPRRNSK TSIFSFRGRA KDVGSENDFA DDEHSTFEDS
     ESRRDSLFVP HRHGERRNSN VSQASMSSRM VPGLPANGKM HSTVDCNGVV SLVGGPSALT
     SPTGQLPPEG TTTETEVRKR RLSSYQISME MLEDSSGRQR AMSIASILTN TMEELEESRQ
     KCPPCWYRFA NVFLIWDCCD AWLKVKHLVN LIVMDPFVDL AITICIVLNT LFMAMEHYPM
     TGQFSSVLTV GNLVFTGIFT AEMVLKIIAM DPYYYFQEGW NIFDGIIVSL SLMELGLANV
     EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF
     GKSYKECVCK ISSDCQLPRW HMNDFFHSFL IVFRVLCGEW IETMWDCMEV AGQTMCLIVF
     MLVMVIGNLV VLNLFLALLL SSFSSDNLAA TDDDNEMNNL QIAVGRMQKG IDYVKNKIRE
     CFRKTFFRKP KVIEIHEGNK IDSCISNNTG IEISKELNYL KDGNGTTSGV GTGSSVEKYV
     IDENDYMSFI NNPSLTVTVP IAVGESDFEN LNTEEFSSES ELEESKEKLN ATSSSEGSTV
     DVAPPREGEQ AEIEPEEDLK PEACFTEGCI KKFPFCQVSI EEGKGKVWWN LRKTCYSIVE
     HNWFETFIVF MILLSSGALA FEDIYIEQRK TIKTMLEYAD KVFTYIFILE MLLKWVAYGF
     QTYFTNAWCW LDFLIVDVSL VSLVANALGY SELGAIKSLR TLRALRPLRA LSRFEGMRVV
     VNALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFYHC VNTTTGNMFE VSEVNNLSDC
     QALGKQARWK NVKVNFDNVG AGYLALLQVA TFKGWMDIMY AAVDSRDVKL QPVYEENLYM
     YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN AMKKLGSKKP
     QKPIPRPANK FQGMVFDFVT RQVFDISIMI LICLNMVTMM VETDDQSKYM TLVLSRINLV
     FIILFTGEFV LKLVSLRYYY FTIGWNIFDF VVVILSIVGM FLAELIEKYF VSPTLFRVIR
     LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGI DDMFNFETFG
     NSMICLFQIT TSAGWDGLLA PILNSAPPDC DPDTIHPGSS VKGDCGNPSV GIFFFVSYII
     ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV WEKFDPDATQ FIEFCKLSDF
     AAALDPPLLI AKPNKVQLIA MDLPMVSGDR IHCLDILFAF TKRVLGESGE MDALRIQMED
     RFMASNPSKV SYEPITTTLK RKQEEVSAAI IQRNFRCYLL RQRLKKVSSE YNKEAIKGRI
     DLPIKEDMII DKLNGNSTPE KTDGSSSTTS PPSYDSVTKP DKEKFEKDKP EKESKGKEGR
     ENQK
//
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