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Database: UniProt
Entry: M3XNN5_MUSPF
LinkDB: M3XNN5_MUSPF
Original site: M3XNN5_MUSPF 
ID   M3XNN5_MUSPF            Unreviewed;      1938 AA.
AC   M3XNN5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN1A {ECO:0000313|Ensembl:ENSMPUP00000000685};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000685, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000000685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000000685};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000000685}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000000685}.
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DR   EMBL; AEYP01014824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000000685; -.
DR   Ensembl; ENSMPUT00000000697; ENSMPUP00000000685; ENSMPUG00000000687.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3XNN5; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050884; P:neuromuscular process controlling posture; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0019227; P:neuronal action potential propagation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    163    184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    190    210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    339    366       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    689    713       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    725    746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    808    836       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    895    921       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1148   1166       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1187   1206       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1262   1290       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1388   1412       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1471   1489       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1501   1519       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1531   1551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1588   1616       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1692   1715       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       70    373       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      445    647       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      698    925       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      935   1142       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1146   1420       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1470   1725       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      363    408       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1938 AA;  221687 MW;  CC498BF2540CE520 CRC64;
     MVIKMCRMTR WSKQCLYHQD LTASTSSPEN LLLLLKDALQ KKRLRIPNQT RKMMMKMAQS
     QIVTWKLERT FLLFMETSLQ RWCQSLWRTW TRTISIKKYT FTGIYTFESL IKIIARGFCL
     EDFTFLRDPW NWLDFTVITF AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIERNVTMNY
     NGTLVNETRF EFDWKSYIQD TRYHYFLEGV LDALLCGNSS DAGQCPEGYV CVKAGRNPNY
     GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM IFFVLVIFLG SFYLINLILA
     VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ LKKQQEAAQQ AAAVTASEHS REPSATGGLS
     DSSSEASKLS SKSAKERRNR RKKRKQKEQS GGEEKDEDEF HKSESEDSIR RKGFRFSIEG
     NRLTYEKRYS SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED
     NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAVFPANGK MHSTVDCNGV VSLVGGPSVP
     TSPVGQLLPE GTTTETEMRK RRSSSFHVSM DFLEDPSQRQ RAMSIASILT NTVEELEESR
     QKCPPCWYKF SNIFLIWDCS PYWLKVKHIV NLVVMDPFVD LAITICIVLN TLFMAMEHYP
     MTEHFNNVLT VGNLVFTGIF TAEMFLKIIA MDPYYYFQEG WNIFDGFIVT LSLVELGLAN
     VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL
     FGKSYKDCVC KISTSCELPR WHMNDFFHSF LIVFRVLCGE WIETMWDCME VAGQAMCLTV
     FMMVMVIGNL VVLNLFLALL LSSFSADNLA ATDDDNEMNN LQIAVDRMHK GVAYVKRKIY
     EFIQQSFVRK QKILDEIKPL DDLNNKKDSC MSNHTTEIGK DLDYLKDVNG TTSGIGTGSS
     VEKYIIDESD YMSFINNPSL TVTVPIAVGE SDFENLNTED FSSESDLEES KEKLNESSSS
     SEGSTVDIGA PAEEQPVVEP EETLEPEACF TEGCVQRFKC CQISVEEGRG KQWWNLRRTC
     FRIVEHNWFE TFIVFMILLS SGALAFEDIY IDQRKTIKTM LEYADKVFTY IFILEMLLKW
     VAYGYQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA IKSLRTLRAL RPLRALSRFE
     GMRVVVNALL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCINTTT GDMFDINEVN
     NHSDCLKLIE RNETARWKNV KVNFDNVGFG YLSLLQVATF KGWMDIMYAA VDSRNVELQP
     KYEESLYMYL YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM
     KKLGSKKPQK PIPRPGNKFQ GMVFDFVTRQ VFDISIMILI CLNMVTMMVE TDDQSDYVTN
     ILSRINLVFI VLFTGECVLK LISLRHYYFT IGWNIFDFVV VILSIVGMFL AELIEKYFVS
     PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYAIFGMSN
     FAYVKREVGI DDMFNFETFG NSMICLFQIT TSAGWDGLLA PILNSKPPDC DPNKVNPGSS
     VKGDCGNPSV GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV
     WEKFDPDATQ FMEFEKLSQF AAALEPPLNL PQPNKLQLIA MDLPMVSGDR IHCLDILFAF
     TKRVLGESGE MDALRIQMEE RFMASNPSKV SYQPITTTLK RKQEEVSAVI IQRAYRRHLL
     KRTVKQASFT YNKNKIKGGA NLLVKEDMII DRINENSITE KTDLTMSTAA CPPSYDRVTK
     PIVEKHEQEG KDEKAKGK
//
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