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Database: UniProt
Entry: M3XNN9_MUSPF
LinkDB: M3XNN9_MUSPF
Original site: M3XNN9_MUSPF 
ID   M3XNN9_MUSPF            Unreviewed;      1847 AA.
AC   M3XNN9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSMPUP00000000689};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000689, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000000689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000000689};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000000689}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000000689}.
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DR   EMBL; AEYP01014829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMPUT00000000701; ENSMPUP00000000689; ENSMPUG00000000691.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF235; PTHR10037:SF235; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1847       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5004043642.
FT   TRANSMEM     61     80       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     92    113       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    119    138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    209    228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    248    275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    596    622       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    634    652       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    672    693       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    714    742       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    804    827       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1052   1070       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1091   1107       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1119   1139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1168   1194       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1293   1316       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1375   1393       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1405   1423       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1435   1455       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1492   1520       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1596   1619       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    281       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      354    553       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      604    832       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      841   1046       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1050   1325       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1374   1629       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      272    310       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1847 AA;  210416 MW;  F479B1B82D49ACBC CRC64;
     MLIMCTILTN CIFMTMSNPP DWTKNVEYTF TGIYTFESLV KILARGFCVG EFTFLRDPWN
     WLDFVVIVFA YLTEFVNLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM
     ILTVFCLSVF ALIGLQLFMG NLKHKCLRDP LENNETLESI IDTLEEEDYK KYFYYLEGSK
     DALLCGLSTD SGQCPEGYRC VKAGRNPDYG YTSFDTFSWA FLALFRLMTQ DYWENLYQQT
     LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL
     KKEQEEAEAI AIAAAEYTSI GRSRMMGFSE SSSETSKLSS KSAKERRNRR KKRNQKKLSS
     GEEKGDNEKL SKSESEESIR RQSFHLGVEG HRRAHEKRLT TPNQSPLSIR GSLFSGRRSS
     RTSLFSFKGR GKDMGSETEF ADDEHSIFGD SESRRGSLFV PHRARERRGS NISQASRSPP
     VPPVKGKMHS AVDCNGVVSL VDGPSALMLP NGQLLPEGTT NQIHKKRRSS SYILSEDMLN
     DPNLRQRAMS RVSILTNTVE ELEESRQKCP PWWYRFAHTF LIWNCSPYWI KFKKLVYFIV
     MDPFVDLAIT ICIVLNTMFM AMEHHPMTEE FKNVLAVGNL VFTGIFAAEM VLKLIAMDPY
     EYFQIGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN
     SVGALGNLTL VLAIIVFIFA VVGMQLFGKN YKECVCKINE DCILPRWHMN DFFHSFLIVF
     RVLCGEWIET MWDCMEVAGQ AMCLIVYMMV MVIGNLVVLN LFLALLLSSF SSDNLTAIEE
     DTDANNLQIA VARITKGINY VKQTLREFIL KAFSKKPKVS KDTGRAEDQN SKKENYISNR
     TLAEMNRDHN YHKEKDQISG FGSSVDKYLM EESDCQSFIH NPSLTVTVPI APGESDLENM
     NTEELSSDSE SEYSKGRLNR SSSSECSTVD NPLPGEGEEA EAEPVNSDEP EACFTDGCVR
     RFPCCQVDIE SGKGKIWWNI RKTCYRIVEH SWFESFIVLM ILLSSGALAF EDIYIEKKKT
     IKIILEYADK IFTYVFILEM LLKWVAYGYK TYFTNAWCWL DFLIVDVSLV TLVASTLGYS
     DLGPIKSLRT LRALRPLRAL SRFEGMRVVV NALIGAIPSI MNVLLVCLIF WLIFSIMGVN
     LFAGKFYQCV NTTDGSRFPT NLVQNRSDCY ALMNVSQNVR WKNLKVNFDN VGLGYLSLLQ
     VATFKGWMDI MYAAVDNVNV DEQPIYEYNL YMYIYFVIFI IFGSFFTLNL FIGVIIDNFN
     QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK KPQKPIPRPG NKFQGCIFDL VTNQAFDITI
     MVLICLNMVT MMVEKEGQSK YMTDVLYWIN VVFIILFTGE CVLKLISLRH YYFTIGWNIF
     DFVVVILSIV GMFLAELIEK YFVSPTLFRV IRLARIGRIL RLIKGAKGIR TLLFALMMSL
     PALFNIGLLL FLVMFIYAIF GMSNFAYVKK EAGINDMFNF ETFGNSMICL FQITTSAGWD
     GLLAPILNSA PPDCDPKKVH PGSSVEGDCG NPSVGIFYFV SYIIISFLVV VNMYIAVILE
     NFSVATEEST EPLSEDDFEM FYEVWEKFDP DATQFIEYSK LSDFAAALDP PLLIAKPNKV
     QLIAMDLPMV SGDRIHCLDI LFAFTKRVLG ESGEMDSLRS QMEERFMSAN PSKVSYEPIT
     TTLKRKQEDV SATVIQRAYR RYRLRQNVKN ISSIYIKDGD RDDGLPSKED MVFDNTNENS
     SPEKTDATPS TVSPPSYDSV TKPEKEKYET DKAEKEDKGK DGKESKK
//
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