GenomeNet

Database: UniProt
Entry: M3XNQ4_MUSPF
LinkDB: M3XNQ4_MUSPF
Original site: M3XNQ4_MUSPF 
ID   M3XNQ4_MUSPF            Unreviewed;      1685 AA.
AC   M3XNQ4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSMPUP00000000704};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000704, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000000704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000000704};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000000704}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000000704}.
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DR   EMBL; AEYP01014831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01014834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000000704; -.
DR   Ensembl; ENSMPUT00000000716; ENSMPUP00000000704; ENSMPUG00000000705.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3XNQ4; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    114    136       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    148    167       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    259       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    368    392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    502    525       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    537    555       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    576    599       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    619    644       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    708    728       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    971    989       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1001   1018       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1047   1073       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1168   1195       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1244   1271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1283   1301       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1372   1400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1476   1502       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      117    403       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      507    730       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      744    928       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      934   1199       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1252   1503       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1685 AA;  193740 MW;  3024A822362F75F6 CRC64;
     EMTSPEQKGL VPFTRESLEL MKQHIAKKHS EDQRDLKPNT DLEVGKELPF VYGNLSPGMV
     LEPLEDVDPY YKNKNTFMVL NKSRTIFRFS ATWCTLSPFN SARRTTIKIL VHPYLTFFRL
     FILISVLIDC IFMSMTEMPK WGPAIQNILL GIYTFEILVK LIARGIWAEP FYFFGDPWNW
     LDFSVTLFEH ITRYLLLGSN TIIFSISRNL RILKIIPLNQ GLKSFTGILI HCLKKLTGVI
     SLTLFFLTVF SLIGMGLFMG NLKHKCLRWP QENETSTLHN RTENPYYMRE TENFYYLEGE
     RYALLCGNRT DAGQCPEGYV CVKAGTNPDY GFTNFDTFGW ALLALFRLMT QDYPEALYHQ
     ILYASGKVYM IFFVVISFWF AFYIASLFLG ILAMSYEEEK QKAAEKAKKI EPKFQQTSKE
     HQEGDKAVET KTTQIEMKKR SPTSVITSLN MLDDATAAIR HEEESEKSRK RCPLCWQRFA
     KTFLIWNCSP CWLKWKEFIH MIIMDPFTDL VLTICIILNI CFLALECYPM SEETNNVLSI
     GNLIFIGIFT AEMILKIIAM HPYGYFQVGW NIFDSLIVFH GLAELYLANI HGVALFRTFR
     VVTLKLAKYW PTFKILMQIL SISLVALKDL VLLLFTFAFF SAVVGLKLFG MSYEACVCNI
     DKDCRLPRWH MHDFFHSYLN VFRILCGEWI ETLWDCFKIA GQFSCISFYM MVILIGNLLI
     IYLFLALVSS FSSYNPATTE ENEEAKNLQR AVATIQKRIN YVISKILCKK QNVSKETMDH
     VNAVYAKENI SDHTLSELSN TQEFLKDKEK SSSTEKNTMT ENESQSLIPS PSASETVPIA
     SGESDIENLD NKEVQSKSGD GNSKEKVKQS SSSECSTVDI AISEEEEIVY EHEKPKHLKN
     GYRRRSSPGQ LSRASKRGRI WQNIRKTCCK IVENSCFKCF IGLVTLLSTG ALAFEDIYID
     QRKTIKILLE YADMIFTYIF ILEMLLKWMA YGFKAYFTNG WYKLDFMVVL VFCLSLIGKS
     REEFKPLTSI KFLRALRVLS QFERMKVVVR ALITTTLPAL NVFLVCLLIW LAFSIMGVHL
     FAGKFYECID PTSGERFPIS EVMNKSQCES LVFNESMPWE NAKLNFDNVG NGFLSLLQVA
     TFNGWITIMN SAVDSVGVNR QPNFEENIYM YCYFINFIII GLFLPLSMLI GVIIANFNMH
     KIKQGGSNIF VTVKQKKQSH ALRRLLCEES QKTIRRPGNK FQGFVFDLVT SEVFNAIIMA
     LICFQAITIM IQSDEQSKNM NITLYWINLV LIILYTGECV LKLIAFHCNY FTIGWNIFDF
     MVVIFSVIDQ ELVLPITVGY YLVSPSIMEL IRLSRIIHIL RPGKGPKVFH DLLLPLMLSL
     PALLNISLLI FLVMFVYAIF GMYNFAYVKK EAGINDVSNF ETFGSSMLCL FQVTIFAGWD
     GMLNAIFNSK WSDCDPDKIN PGTQVRGDCG NPFVGIIYFV SYILISWLII VNMYIVVVME
     FLNIVSKKKA KTLSEDDFRK FFQVWKRFDP DRTQYIDSSR LSDFAAALDP PLFMAKPNKG
     QLVAMDLPMA AGDRIHCLDI LLALTKRVMG KDVRMEKMIS EMESGFVLAN PFKITYEPIT
     TTLKRKQEAV SATIIQRAYK SYRLRQNDKN TSDIHMIDDD KEVQATTEKA YFDKAEEKST
     IQSQI
//
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