ID M3XP35_MUSPF Unreviewed; 332 AA.
AC M3XP35;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Distal-less homeobox 2 {ECO:0000313|Ensembl:ENSMPUP00000000835.1};
DE SubName: Full=Homeobox protein DLX-2 {ECO:0000313|RefSeq:XP_004744134.1};
GN Name=DLX2 {ECO:0000313|Ensembl:ENSMPUP00000000835.1,
GN ECO:0000313|RefSeq:XP_004744134.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000000835.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000000835.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004744134.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004744134.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family.
CC {ECO:0000256|ARBA:ARBA00007916}.
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DR EMBL; AEYP01015019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004744134.1; XM_004744077.3.
DR STRING; 9669.ENSMPUP00000000835; -.
DR Ensembl; ENSMPUT00000000851.1; ENSMPUP00000000835.1; ENSMPUG00000000839.1.
DR GeneID; 101682242; -.
DR KEGG; mpuf:101682242; -.
DR CTD; 1746; -.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000160127; -.
DR HOGENOM; CLU_074733_1_1_1; -.
DR OMA; WYHQASS; -.
DR OrthoDB; 2969529at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0048755; P:branching morphogenesis of a nerve; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0021893; P:cerebral cortex GABAergic interneuron fate commitment; IEA:Ensembl.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR GO; GO:0021879; P:forebrain neuron differentiation; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0014016; P:neuroblast differentiation; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR GO; GO:0021772; P:olfactory bulb development; IEA:Ensembl.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:1902871; P:positive regulation of amacrine cell differentiation; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
DR GO; GO:0021544; P:subpallium development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR022135; Distal-less_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24327:SF23; HOMEOBOX PROTEIN DLX-2; 1.
DR Pfam; PF12413; DLL_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 148..208
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 150..209
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 19..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..321
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 34868 MW; 3C050DC00FB611F7 CRC64;
MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGGGAGPGGS NGSSLHKPQE SPTLPVSTAT
DSSYYTNQQH PAGGGGSGGS PYAHMGSYQY HAGGLNNVPY SAKSGYDLGY TAAYTSYAPY
GTSSSPANNE PEKEDLEPEI RIVNGKPKKV RKPRTIYSSF QLAALQRRFQ KTQYLALPER
AELAASLGLT QTQVKIWFQN RRSKFKKMWK SGEIPSEQHP GASTSPPCAS PPVSAPASWD
FSAPQRMGSG GGPGSGGSGA GSSGSSPSSA ASAFLGNYPW YHQASGPASH LQAAAPLLHP
TQTPQPHHHH HHHHHHHHHG GGGAPVSAGT IF
//
