GenomeNet

Database: UniProt
Entry: M3XU28_MUSPF
LinkDB: M3XU28_MUSPF
Original site: M3XU28_MUSPF 
ID   M3XU28_MUSPF            Unreviewed;       861 AA.
AC   M3XU28;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSMPUP00000002578};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSMPUP00000002578};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002578, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000002578}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000002578};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000002578}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000002578}.
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DR   EMBL; AEYP01033675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01033676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01033677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012912014.1; XM_013056560.1.
DR   Ensembl; ENSMPUT00000002632; ENSMPUP00000002578; ENSMPUG00000002608.
DR   GeneID; 101682776; -.
DR   CTD; 53373; -.
DR   eggNOG; ENOG410INF7; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; M3XU28; -.
DR   OMA; WLGFHTF; -.
DR   OrthoDB; EOG091G038K; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF262; PTHR10037:SF262; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    150    172       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    343    366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    520    538       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    550    569       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    613    637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    709    734       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      156    373       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      484    733       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   861 AA;  98968 MW;  3C6F1B5B860AADAA CRC64;
     MAVSLDDDVP LILTLDEGGG GPLAPSNGLG QEEVPSRSRL PPRNADMQRP GSAAVFLLEE
     VVEGQLPDSP VARSSRLHQM GPCDGGSYAV HDSRTPSLGS GDESPTGHNW EINYQEAAIY
     LQEGENNDKF FTHPKNAKAL AAYLFAHNHL FYLMELSTAL LLLLLSLCEA PAVPALRLGI
     YVHATLELFA LMVVVFELCM KLRWLGLHTF IRHRRTMVKT SVLVVQFVEA IVVLVRQTSH
     VRVTRALRCI FLVDCRYCGG VRRNLRQIFQ SLPPFMDILL LLLFFMVIFA ILGFYLFSPN
     PSDPYFSTLE NSIVSLFVLL TTANFPDVMM PSYSRNPWSC VFFIVYLSIE LYFIMNLLLA
     VVFDTFNDIE KRKFKSLLLH KRTAIQHAYR LLISQRRPAG ISYRQFEGLM RFYRPRMSAR
     ERYLTFKALN QSNTPLLSLK DFYDIYEVAA LKWKAKRNRE HWFDELPRTA FLIFKGINIL
     VKSKAFQYFM YLVVAVNGVW ILVETFMLKG GNFFSKQVPW SYVVFLTIYG VELFLKVAGL
     GPVQYLSSGW NLFDFSVTVF AFLGLLALAF DMEPFYFIVV LRPLQLLRLF KLKKRYRNVL
     DTMFELLPRM ASLGLTLLIF YYSFAIVGME FFCGILYPNC CNTSTVADAY RWLNHTVGNE
     TVVDEGYYYL NNFDNILNSF VTLFELTVVN NWYIIMEGVT SQTSHWSRLY FMTFYIVTMV
     VMTIIVAFIL EAFVFRMNYS RKNQDSEVDS GITLEKEISK DELTAVLELY REGRGAASDM
     ARLLKVLSQM ERHEQNTVVF LGRRSRTKSD LSLKMYQEEI QEWYEEHARK QEQQEGPFGG
     SGRGPATQQL PGSRQRSQTV T
//
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