ID M3XV86_MUSPF Unreviewed; 2928 AA.
AC M3XV86;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Cadherin EGF LAG seven-pass G-type receptor 2 {ECO:0000313|Ensembl:ENSMPUP00000002986.1};
GN Name=CELSR2 {ECO:0000313|Ensembl:ENSMPUP00000002986.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002986.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000002986.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Receptor that may have an important role in cell/cell
CC signaling during nervous system formation.
CC {ECO:0000256|ARBA:ARBA00002066}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7
CC subfamily. {ECO:0000256|ARBA:ARBA00010933}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AEYP01073765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01073766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01073767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000002986; -.
DR Ensembl; ENSMPUT00000003047.1; ENSMPUP00000002986.1; ENSMPUG00000003016.1.
DR eggNOG; KOG4289; Eukaryota.
DR GeneTree; ENSGT00940000157493; -.
DR HOGENOM; CLU_000158_1_0_1; -.
DR InParanoid; M3XV86; -.
DR OMA; FTLYIVE; -.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0033326; P:cerebrospinal fluid secretion; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0003341; P:cilium movement; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0097475; P:motor neuron migration; IEA:Ensembl.
DR GO; GO:0021999; P:neural plate anterior/posterior regionalization; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 9.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00055; EGF_Lam; 1.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 9.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24026:SF32; CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2; 1.
DR PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00053; Laminin_EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00112; CA; 9.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00180; EGF_Lam; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 9.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 7.
DR PROSITE; PS50268; CADHERIN_2; 9.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..2928
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004043862"
FT TRANSMEM 2384..2406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2418..2434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2440..2464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2485..2505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2525..2546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2567..2588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2594..2617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 187..294
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 295..404
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 405..510
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 511..615
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 616..717
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 718..820
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 821..926
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 927..1028
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1047..1151
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1233..1291
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1293..1329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1333..1371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1372..1576
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1579..1615
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1619..1796
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1834..1872
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1929..1976
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1961..2034
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 2381..2618
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 2219..2243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2693..2901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2746..2760
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2858..2877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1281..1290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1319..1328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1605..1614
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1862..1871
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1929..1941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1931..1948
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1950..1959
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 2928 AA; 317663 MW; E7442D9A8C4BB4BF CRC64;
RKSPSAVPVE TGVILPSSWT PRSILLLLLL LPPLLGDQVG PCRSLGPGGR GSSGACAPVG
WLCPASASNL WLYTSRCRDA GTELTGHLVP HHDGLRVWCP ESGAHIPLPP APEGCPWSCR
LLGIGGHLSP QGKLTLPQEH PCLKAPRLRC QSCKLMQTPG LRAGERSTEE SMGGRWKRNV
NTAPQFQPPS YQATVPENQP AGTPVASLRA IDPDEGEAGR LEYTMDALFD SRSKHFFSLD
PITGAVTTAE ELDRETKSTH VFRVTAQDHG MPRRSALATL TILVTDTNDH DPVFEQQEYK
ESLRENLEVG YEVLTVRATD GDAPPNANIL YRLLEGPGGS PSEVFEIDPR SGVIRTRGPV
DREEVESYQL TVEASDQGRD PGPRSATAAV FLSVEDDNDN APQFSEKRYV VQVREDVTPG
APVLRVTASD RDKGSNALVH YSIMSGNARG QFYLDAQTGA LDVVSPLDYE TTKEYTLRVR
AQDGGRPPLS NVSGLVTVQV LDINDNAPIF VSTPFQATVL ESVPLGYLVL HVQAIDADAG
DNARLEYRLA GVGHDFPFAI NNGTGWISVA AELDREEVDF YSFGVEARDH GTPMLTASAS
VSVTILDVND NNPTFTQPEY TVRLNEDAAV GTSVVTVSAV DRDAHSVITY QITSGNTRNR
FSITSQSGGG LVSLALPLDY KLERQYVLAV TASDGTRQDT AQVVVNVTDA NTHRPVFQSS
HYTVNVNEDR PAGTTVVLIS ATDEDTGENA RITYFMEDSI PQFRIDADTG AVTTQAELDY
EDQVSYTLAI TARDNGIPQK SDTTYLEILV NDVNDNAPQF LRDSYQGSVY EDVPPFTSVL
QISATDRDSG LNGRVFYTFQ GGDDGDGDFI VESTSGIVRT LRRLDRENVA QYVLRAYAVD
KGMPPARTPM EVTVTVLDVN DNPPVFEQDE FDVFVEENSP IGLAVARVTA TDPDEGTNAQ
IMYQIVEGNI PEVFQLDIFS GELTALVDLD YEDRPEYILV IQATSAPLVS RATVHVRLLD
RNDNPPVLGN FEILFNNYVT NRSSSFPGGA IGRVPAHDPD ISDSLTYSFE RGNELSLVLL
NASTGELRLS RALDNNRPLE AIMSVLVSDG VHSVTAQCAL RVTIITDEML THSITLRLED
MSPERFLSPL LGLFIQAVAA TLATPPDHVV VFNVQRDTDA PGGHILNVSL SVGQPPGPGG
GPPFLPSEDL QERLYLNRSL LTAISAQRVL PFDDNICLRE PCENYMRCVS VLRFDSSAPF
IASSSVLFRP IHPVGGLRCR CPPGFTGDYC ETEVDLCYSR PCGPHGRCRS REGGYTCLCR
DGYTGEHCEV SARSGRCTPG VCKNGGTCVN LLVGGFKCDC PSGDFEKPYC QVTTRSFPAR
SFITFRGLRQ RFHFTLALSF ATKERDGLLL YNGRFNEKHD FVALEVIQEQ VQLTFSAGES
TTTVSPFVPG GVSDGQWHTV QLKYYNKPLL GQTGLPQGPS EQKVAVVTVD GCDTGVALRF
GAVLGNYSCA AQGTQGGSKK SLDLTGPLLL GGVPDLPESF PVRTRHFVGC MRNLQVDSRH
VDMADFIANN GTVPGCPAKK NVCDSSTCNN GGTCVNQWDA FSCECPLGFG GKSCAQEMAN
PQRFLGSSLV AWHGLSLPIS QPWHLSLMFR TRQANGVLLQ AVTRGRSTIT LQLREGHVVL
SVEGTGLQAS SLRLEPGRAN DGDWHHAQLA LGASGGPGHA ILSFDYGQQR AEGNLGPRLH
GLHLSNITVG GVPGPAGGVA RGFRGCLQGV RVSETPEGVS GLDPSRGESI NVEPGCSLPD
PCDSNPCPAN SYCSDDWDSY SSCGQPGYYG DNCTNVCDLN PCEHQSVCIR KPSAPHGYTC
ECPQNYLGPY CETRIDQPCP RGWWGHPTCG PCNCDVSKGF DPDCNKTSGE CHCKENHYRP
PGSPTCLLCD CYPTGSLSRV CDPEDGQCPC KPGVIGRQCD RCDNPFAEVT TNGCEVNYDS
CPRAIEAGIW WPRTRFGLPA AAPCPKGSFG TAVRHCDEHR GWLPPSLFNC TSVTFSELKG
FAERLQRNES GLDSGRSQRL ALLLRNATQH TAGYFGSDVK VAYQLATRLL AHESAQRGFG
LSATQDVHFT ENLLRVGSAL LDAANKRHWE LIQQTEGGTA WLLQHYEAYA SALAQNMRHT
YLNPFTIITP NIVISVVRLD KGNFAGAKLP RYEALRGERP PDLETTVILP DSVFRETPTM
VRPAGPGEAQ EPEELARRQR RHPELSQGEA VASVIIYRTL AGLLPHNYDP DKRSLRVPKR
PVINTPVVSI SVHDDEELLP RALDKPVTVQ FRLLETEERT KPICVFWNHS ILVSGTGGWS
ARGCEVVFRN ESHVSCQCNH MTSFAVLMDV SRRENGEILP LKTLTYVALG VTLAALLLAF
LFLTVLRALR SNQHGIRRNL TAALGLAQLV FLLGINQADL PFACTVIAIL LHFLYLCTFS
WALLEALHLY RALTEVRDVN AGPMRFYYML GWGVPAFITG LAVGLDPEGY GNPDFCWLSI
YDTLIWSFAG PVAFAVSMSV FLYILAARAS CAAQRQGFEK KGPVSGLRPS FAVLLLLSAT
WLLALLSVNS DTLLFHYLFA ACNCVQGPFI LLSYVVLSKE VRKALKFACS RKASPDPALT
TKSTLTSSYN CPSPYADGRL YQPYGDSAGS LHSASRSGKS QPSYIPFLLR EESTLNPGQG
PPGLGDPGSL FLEGQDQQHD PDTDSDSDLS LEDDQSGSYA STHSSDSEEE EEEEEEGAVF
PGEPGWDSLL GPGAERLPLH STPKDGGPGP GKAPWPGDFG TTAKESSGNG ASEERPWENG
DVLPREGSLG PLPGPSAQPH KGILKKKCLP TISEKSSLLR LPLEQGTGSS RGSSASEGSR
GGPPPRPPPR QSLQEQLNGV MPIAMSIKAG TVDEDSSGSE FLFFNFLH
//
