ID M3XZK8_MUSPF Unreviewed; 380 AA.
AC M3XZK8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=G protein subunit alpha L {ECO:0000313|Ensembl:ENSMPUP00000004509.1};
DE SubName: Full=Guanine nucleotide-binding protein G(Olf) subunit alpha isoform X2 {ECO:0000313|RefSeq:XP_004742746.1};
GN Name=GNAL {ECO:0000313|Ensembl:ENSMPUP00000004509.1,
GN ECO:0000313|RefSeq:XP_004742746.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000004509.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000004509.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004742746.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004742746.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
CC {ECO:0000256|ARBA:ARBA00007172}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01011406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01011407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004742746.1; XM_004742689.3.
DR RefSeq; XP_004742747.1; XM_004742690.2.
DR STRING; 9669.ENSMPUP00000004509; -.
DR Ensembl; ENSMPUT00000004588.1; ENSMPUP00000004509.1; ENSMPUG00000004545.1.
DR GeneID; 101687077; -.
DR KEGG; mpuf:101687077; -.
DR CTD; 2774; -.
DR eggNOG; KOG0099; Eukaryota.
DR GeneTree; ENSGT00940000155271; -.
DR HOGENOM; CLU_014184_3_0_1; -.
DR OMA; KEFFEHA; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000367; Gprotein_alpha_S.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF233; GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00443; GPROTEINAS.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 44221 MW; D88F6395CFC1C02D CRC64;
MGCLGNSKTA EDQGVDEKER REANKKIEKQ LQKERLAYKA THRLLLLGAG ESGKSTIVKQ
MRILHVNGFN PEEKKQKILD IRKNVKDAIV TIVSAMSTII PPVPLANPEN QFRSDYIKSI
APITDFEYSQ EFFDHVKKLW DDEGVKACFE RSNEYQLIDC AQYFLERIDS VSLVDYTPTD
QDLLRCRVLT SGIFETRFQV DKVNFHMFDV GGQRDERRKW IQCFNDVTAI IYVAACSSYN
MVIREDNNTN RLRESLDLFE SIWNNRWLRT ISIILFLNKQ DMLAEKVLAG KSKIEDYFPE
YANYTVPEDA TPDAGEDPKV TRAKFFIRDL FLRISTATGD GKHYCYPHFT CAVDTENIRR
VFNDCRDIIQ RMHLKQYELL
//
