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Database: UniProt
Entry: M3Y169_MUSPF
LinkDB: M3Y169_MUSPF
Original site: M3Y169_MUSPF 
ID   M3Y169_MUSPF            Unreviewed;       590 AA.
AC   M3Y169;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   30-AUG-2017, entry version 33.
DE   SubName: Full=Potassium voltage-gated channel subfamily Q member 1 {ECO:0000313|Ensembl:ENSMPUP00000005070};
GN   Name=KCNQ1 {ECO:0000313|Ensembl:ENSMPUP00000005070};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005070, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000005070}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000005070};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000005070}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000005070}.
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DR   EMBL; AEYP01049463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01049472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000005070; -.
DR   Ensembl; ENSMPUT00000005155; ENSMPUP00000005070; ENSMPUG00000005108.
DR   eggNOG; KOG1419; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00550000074513; -.
DR   InParanoid; M3Y169; -.
DR   OMA; ERKRWGW; -.
DR   OrthoDB; EOG091G02ZT; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086089; F:voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:1902282; F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:0072358; P:cardiovascular system development; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
DR   GO; GO:0016458; P:gene silencing; IEA:Ensembl.
DR   GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR   GO; GO:0098914; P:membrane repolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0060452; P:positive regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:1901381; P:positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
DR   GO; GO:0097623; P:potassium ion export across plasma membrane; IEA:Ensembl.
DR   GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0060453; P:regulation of gastric acid secretion; IEA:Ensembl.
DR   GO; GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0070293; P:renal absorption; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF189; PTHR11537:SF189; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01460; KCNQ1CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     42     62       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     74     93       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    114    132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    179    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    244    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       47    271       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      421    535       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
SQ   SEQUENCE   590 AA;  65480 MW;  92125FB2D1FCC44E CRC64;
     MAGWVRPAPG TCSPAGGLLR VLGSWGGGRA GRLAARADRR VLLPRSFLIV LVCLIFSVLS
     TIEQYVTLAT GTLFWMEIVL VVFFGTEYVV RLWSAGCRSK YVGIWGRLRF ARKPISIIDL
     IVVLASMVVL CVGSKGQVFA TSAIRGIRFL QILRMLHVDR QGGTWRLLGS VVFIHRQELI
     TTLYIGFLGL IFSSYFVYLA EKDAVNDSGQ VEFGSYADAL WWGVVTVTTI GYGDKVPQTW
     VGKTIASCFS VFAISFFALP AGILGSGFAL KVQQKQRQKH FNRQIPAAAS LIQTAWRCYA
     AENPESCTWK VYVRKPARSH ALLSPSPKPK KSVMVKRKKF KLDKDNGLNP GEKVLTVPHI
     TCEPVSEDRK PDHFSVDSCD SSARKSPMLL EVSPAHFMRT NSFAEDLDLE GETLLAPITH
     VSQLREHHRA TIKVIRRMQY FVAKKKFQQA RKPYDVRDVI EQYSQGHLNL MVRIKELQRR
     LDQSIGKPSL FISVSEKTKD RGSNTVGARL NRVEDKVTQL DQRLVLITDM LRQLLSLHQG
     GRPGERTPGG GGAQAPPPCG SLSPELFLPS GALPTYEQLT VPRGGPDEGS
//
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