ID M3Y1I4_MUSPF Unreviewed; 844 AA.
AC M3Y1I4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator like 3 {ECO:0000313|Ensembl:ENSMPUP00000005185.1};
GN Name=RGL3 {ECO:0000313|Ensembl:ENSMPUP00000005185.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005185.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005185.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
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DR EMBL; AEYP01024472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01024473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01024474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3Y1I4; -.
DR STRING; 9669.ENSMPUP00000005185; -.
DR Ensembl; ENSMPUT00000005272.1; ENSMPUP00000005185.1; ENSMPUG00000005222.1.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000161935; -.
DR HOGENOM; CLU_010252_1_1_1; -.
DR InParanoid; M3Y1I4; -.
DR OMA; RLSWVIE; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17212; RA_RGL3; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR030750; RGL3_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF220; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 60..208
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 338..608
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 759..844
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 115..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..138
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..698
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 91277 MW; BB47578286187212 CRC64;
ARLRVQAPVQ DWGEEAEDGA VYSVSLRRQL SQRLSPRAAP GASQASNPAA DAFLHYRTSK
VRALRAARLE RLVQELVSGD REQDPGFVPA FLATHRAFAS TARVLGLLLP PPPPPLPPGV
LDPAFPTPKS PQPPSSPDGR VAFPRTEIKK AVVSVLGSWL RDHPQDFRDP PAHSDLGSVR
TFLGWAAPAG PEAQEAEKLL GAFLEEAEQK QEEEEKPEAW TGEGYRVPEQ AFPCIICPPV
AVFAQLVPFS DLQANIAFHS GTPLENPTTE KPPLTTDRSC SKPKTPLFPT LACSVTRYLG
TPSGPPGAVH SPRPDSPEDC SEAEAGPVRE GPELLDFSVD ELAEQLTLLD VELFARVRSC
ECLGSVWSQR DRPGAASTAP TVRATVTQFN LVTGCVLGSV LGEQGLAAPQ RAQRLEKWIR
VAQRCRELRN FSSLRAILSA LQSNPIYRLK RSWGAVSRER LSTFRKLSQI FSDENNHLSS
REILSQQIRI RGQGTGSSEF SSCWVPGTVP VVAESKTGVC AGPVPYLGTF LTDLVMLDTA
LPDMLEGDLI NFEKRRKEWE ILAHIQQLQK RCGSYCLSPR APVLAALRAQ CQLSEEQSYR
VSRVIEPPAA SCPSSPHVRR RISPTKRLSA EAAPGASPGS SSSLVSVFRK LSRERRSSPA
GSPGDPSSPT PSLSPGSPPS SPRTRDPPGS PPASPGPQGP NTKVLGSACV GGHKTPPPTQ
PPSSHCLQLP LSLDLPALRL LALPLSSSHI SVPGQPGSEA RVIRVSIDND HGNLYRSILL
TSQDKAPSVV QRALEKHNVA QPWARDYQLF QVLPGDRELL IPDNANVFYA MSPAAPGDFV
LRRK
//
