ID M3Y1Q0_MUSPF Unreviewed; 1188 AA.
AC M3Y1Q0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase {ECO:0000256|ARBA:ARBA00012981};
DE EC=3.1.3.86 {ECO:0000256|ARBA:ARBA00012981};
GN Name=INPP5D {ECO:0000313|Ensembl:ENSMPUP00000005251.1,
GN ECO:0000313|RefSeq:XP_004773560.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005251.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004773560.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004773560.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC family. {ECO:0000256|ARBA:ARBA00008734}.
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DR EMBL; AEYP01081415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01081416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01081417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01081418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01081419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01081420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004773560.1; XM_004773503.3.
DR STRING; 9669.ENSMPUP00000005251; -.
DR Ensembl; ENSMPUT00000005339.1; ENSMPUP00000005251.1; ENSMPUG00000005289.1.
DR GeneID; 101689592; -.
DR KEGG; mpuf:101689592; -.
DR CTD; 3635; -.
DR eggNOG; KOG0565; Eukaryota.
DR GeneTree; ENSGT00940000156202; -.
DR HOGENOM; CLU_007493_0_0_1; -.
DR OMA; DSWFQCK; -.
DR OrthoDB; 21647at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0050777; P:negative regulation of immune response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0045656; P:negative regulation of monocyte differentiation; IEA:Ensembl.
DR GO; GO:0045659; P:negative regulation of neutrophil differentiation; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:Ensembl.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
DR GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR CDD; cd09100; INPP5c_SHIP1-INPP5D; 1.
DR CDD; cd10343; SH2_SHIP; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46051:SF3; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 1; 1.
DR PANTHER; PTHR46051; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 5..101
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 103..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..118
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1188 AA; 133031 MW; 0707C10F213E649B CRC64;
MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV YTYRILPNED
DKFTVQASEG VPMRFFTKLD QLIEFYKKEN MGLVTHLQYP VPLEEEEAGD EPEEETEGVL
SPPELPPRNI PLFAGPCETK DVPLSSENVR ATEVSKPSLS ETLFQRLQSM DTSGLPEEHL
KAIQDYLSTQ LALDSDFVKT GSSSLPHLKK LTTLLCKELY GEVLRTLPSL ESLQRLFDQQ
LSPGLRPRPQ VPGEANPVNM VAKLSQLTSL LSSIEDKVKA LLHEGAESPH RRSLIPPVTF
EVKSESLGIP QKLQLKVDVE SGKLIMKKGK DGSEDKFYPH NKILQLIKSQ KFLNKLVILV
ETEKEKTLRK EYVFADSKKR EGFCQLLQQM KNKHSEQPEP DMITIFIGTW NMGNAPPPKK
ITSWFLSKGQ GKTRDDSADY IPHDIYVIGT QEDPLGEKEW LEILKHSLQE ITSMTFKTIA
IHTLWNIRIV VLAKPEHENR ISHICTDNVK TGIANTLGNK GAVGVSFMFN GTSLGFVNSH
LTSGSEKKLR RNQNYMSILR FLALGDKKLS PFNITHRFTH LFWLGDLNYR VELPTWEAET
IVQKIKQQQY ADLLSHDQLL MERKEQKVFL HFEEEEITFA PTYRFERLTR DKYAYTKQKA
TGMKYNLPSW CDRVLWKSYP LVHVVCQSYG STSDIMTSDH SPVFATFEAG VTSQFVSKNG
PGTVDSQGQI EFLRCFATLK TKSQTKFYLE FHSSCLESFV KSQEGENEEG SEGELVVKFG
ETLPKLKPII SDPEYLLDQH ILISIKSSDS DESYGEGCIA LRLEATETQL PIYTPLTHHG
EMTGHFRGEI KLQTSQGKMR EKLYDFVKTE RDESSGPKSL KSLTSHDPMK QWEPANRVPS
SGSSSITEII NPNYIGVVPF GHMKQSLSPD QQPTAWSYDQ PLKDSSLGPG RGDSPPTPPS
QPPVSPKKFS SSTATRVPCP RTQESRSCDV GKNPAEPSPP EDAQLTKPEM FENPLYGSVS
SFPKPLPRKE QESPKMLRKE ALPCPDPGIV SPSILLPKAQ EAEGNKGTGK PTPTPFLSPT
PRLRSFTCSS SAEGRPAGGD KSQGKAKAPA SLHAQVPAKR PIKPSRSELS PQAPPPPPLA
QRPPLPVKSP AVLHLQHSKG RDYRENAELP HHGKHRPEDA PLSRAAMQ
//
