ID   M3Y1T2_MUSPF            Unreviewed;       966 AA.
AC   M3Y1T2;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSMPUP00000005283.1};
DE   SubName: Full=Sorting nexin-14 isoform X1 {ECO:0000313|RefSeq:XP_004773637.1};
GN   Name=SNX14 {ECO:0000313|Ensembl:ENSMPUP00000005283.1,
GN   ECO:0000313|RefSeq:XP_004773637.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005283.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000005283.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004773637.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004773637.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AEYP01081630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01081631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01081632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01081633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004773637.1; XM_004773580.3.
DR   STRING; 9669.ENSMPUP00000005283; -.
DR   Ensembl; ENSMPUT00000005371.1; ENSMPUP00000005283.1; ENSMPUG00000005321.1.
DR   GeneID; 101685379; -.
DR   KEGG; mpuf:101685379; -.
DR   CTD; 57231; -.
DR   eggNOG; KOG2101; Eukaryota.
DR   GeneTree; ENSGT00950000182856; -.
DR   HOGENOM; CLU_014115_0_0_1; -.
DR   OMA; MYVYVIS; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098794; C:postsynapse; IEA:GOC.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR   GO; GO:0099170; P:postsynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        48..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          150..324
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          356..488
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          590..710
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   966 AA;  111941 MW;  2706FC514934BEF2 CRC64;
     MGVASTSASV CSGTSATPAE MVSWVRAMGE KLKQRLRLDV GREICRQYPL FCFLLLCLSV
     ASLLLNRYLH VLMIFWSFVA GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGRS
     CAVCGKVKCK RHRPSLLLEN YQPWLDLKIS SKVDASLSEV LELVLENFVY PWYRDVTDDE
     SFVDELRITL RFFASVLIRR IHKVDIPSII TKKLLKAAMK HIEVIVKASQ KVENTEFLQQ
     AALEEYGPEL HVALRSRRDE LHYLRKLTEL LFPYILPPKA TDCRSLTLLL REILSGSVFL
     PSLDFLADPD TVNHLLIIFI DDSPPEKATE LPSPLVPFLQ KFAEPRNKKP SVLKLELKHI
     REQQDLLFRF MNFLKQEGAV HVLQICLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY
     CLDESIDKIR FDPFIVEEIQ KIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH
     SDEYFRQLLR GAESPTRNSK LNRGSLSLDD FRSTQKRGES FGISRIGSKI KGVFKSTTME
     GAMLPNYGLA EGEDDFIEEG IVVMEDDSPV EAVSTPNTPR NLAAWKISIP YVDFFEDPSS
     ERKEKKERIP VFCIDVERND RRAVGHEPEH WSVYRRYLEF YVLESKLTEF HGTFPDAQLP
     SKRIIGPKNY EFLKSKREEF QEYLQKLLQH PELSNSQLLA DFLSPNGGET QFLDKILPDV
     NLGKIIKSVP GKLMKEKGQH LEPFIMNFIN SCESSKPKPS KPELTILSPT SENNKKLFSD
     LFKNNANRAE NTERKQNQNY FMEMMTVEGV YDYLMYVGRV VFQVPDWLHH LLMGTRILFK
     NTLEMYTDYY LHCKLEQLFQ EHRLVSLITL LRDAVFCENT EPRSLQDKQK RAKQTFEEMM
     NYIPDLIVKC IGEEAKYESI RLLFDGLQQP VLNKQLTYVL LDIVIQELFP ELNKVQKEVT
     SVTSWM
//