ID   M3Y2N1_MUSPF            Unreviewed;       560 AA.
AC   M3Y2N1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Mucin-1 {ECO:0000256|ARBA:ARBA00014269};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005582.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000005582.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004247}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004247}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AEYP01094770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01094771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012904473.1; XM_013049019.1.
DR   AlphaFoldDB; M3Y2N1; -.
DR   STRING; 9669.ENSMPUP00000005582; -.
DR   Ensembl; ENSMPUT00000005679.1; ENSMPUP00000005582.1; ENSMPUG00000005627.1.
DR   KEGG; mpuf:101688566; -.
DR   eggNOG; ENOG502S4SC; Eukaryota.
DR   GeneTree; ENSGT00710000106874; -.
DR   HOGENOM; CLU_029446_1_0_1; -.
DR   InParanoid; M3Y2N1; -.
DR   OMA; TTPVHNG; -.
DR   OrthoDB; 5363311at2759; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 6.10.140.600; -; 1.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   PANTHER; PTHR10006:SF19; MUCIN-1; 1.
DR   PANTHER; PTHR10006; MUCIN-1-RELATED; 1.
DR   Pfam; PF01390; SEA; 1.
DR   SMART; SM00200; SEA; 1.
DR   SUPFAM; SSF82671; SEA domain; 1.
DR   PROSITE; PS50024; SEA; 1.
PE   4: Predicted;
KW   Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..560
FT                   /note="Mucin-1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004044311"
FT   TRANSMEM        467..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          348..454
FT                   /note="SEA"
FT                   /evidence="ECO:0000259|PROSITE:PS50024"
FT   REGION          25..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  57516 MW;  032830E22A2187F7 CRC64;
     MTPGFQAPLF LLLLAALQLP ADTAQSTDNS FSTTSSASSL TTTPGQHGGS GSTPSSASSL
     TTTPGHHSSR SLSTTPRHHS GPSPNTTTGH HSGTSQTTTT GHHSGPSPNT TPNTTTGHHS
     GPSPNTTTGH HSGTSQTTTT GHHSGPSPTT TTGHHSGPSP TTTTGHHSGP SPTTTTGHHS
     GRSPSTTPGH HSGPTEHHSS RSPSTTPGHH SGPSPSTTPG HHSGPSPSTT PGHHSGPSPS
     TTPGHHSGPS PSTTPGHHSG PSPSTTAGQH SGPSPSTTPG HHSGSSLTTT SRHHGVPTLT
     RSSASSSTAT SGQHGGTSPT HIPPTSTALR GPEPPTPSYH STSPQSLSIS VFSLSFSIEN
     RHFNSSLEDP GSSYYQELQR NISELFWQIY KKEGFLGLFN IKFRAGSVVV ESSLAFRKGA
     TDAHSVQTQL EENKKKFAAY HLSISNVRAQ DVSPLSSGQS GSGVPGWGIA LLVLVCVLVA
     LAIICVIALT VCQCCRKNCG QLDIFPARDA YHPMSEYPTY HTHGRYVPPG SRRSPYEEVS
     AGNGGFASVN PSTSATSANL
//