ID M3Y339_MUSPF Unreviewed; 649 AA.
AC M3Y339;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Ubiquitin associated and SH3 domain containing B {ECO:0000313|Ensembl:ENSMPUP00000005740.1};
DE SubName: Full=Ubiquitin-associated and SH3 domain-containing protein B isoform X1 {ECO:0000313|RefSeq:XP_004750144.1};
GN Name=UBASH3B {ECO:0000313|Ensembl:ENSMPUP00000005740.1,
GN ECO:0000313|RefSeq:XP_004750144.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005740.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005740.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004750144.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004750144.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01026937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01026938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01026939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01026940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01026941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01026942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004750144.1; XM_004750087.3.
DR STRING; 9669.ENSMPUP00000005740; -.
DR Ensembl; ENSMPUT00000005839.1; ENSMPUP00000005740.1; ENSMPUG00000005787.1.
DR GeneID; 101685771; -.
DR KEGG; mpuf:101685771; -.
DR CTD; 84959; -.
DR eggNOG; KOG3734; Eukaryota.
DR GeneTree; ENSGT00940000156097; -.
DR HOGENOM; CLU_016516_1_0_1; -.
DR OMA; NMPKEIP; -.
DR OrthoDB; 5484137at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:Ensembl.
DR GO; GO:0038063; P:collagen-activated tyrosine kinase receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0090331; P:negative regulation of platelet aggregation; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:Ensembl.
DR GO; GO:0070527; P:platelet aggregation; IEA:Ensembl.
DR GO; GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd11936; SH3_UBASH3B; 1.
DR CDD; cd14301; UBA_UBS3B; 1.
DR Gene3D; 3.90.1140.10; Cyclic phosphodiesterase; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR035632; UBASH3B_SH3.
DR PANTHER; PTHR16469; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED; 1.
DR PANTHER; PTHR16469:SF29; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN B; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 27..76
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 254..319
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT SITE 576
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-3"
SQ SEQUENCE 649 AA; 72661 MW; 5C427F24AF3A6EEB CRC64;
MAQYGHPGPL GMAAREELYS KVTPRRSRQQ RPGTIKHGSA LDVLLSMGFP RARAQKALAS
TGGRSVQAAC DWLFSHVGDP FLDDPLPREY VLYLRPTGPL AQKLSDFWQQ SKQICGKNKA
HNIFPHITLC QFFMCEDSKV DALGEALQTT VSRWKCKFSA PLPLELYTSS NFIGLFVKED
SAEVLKKFAA DFAAEAASKT EVHVEPHKKQ LHVTLAYHFQ ASHLPTLEKL AQNIDVKLGC
DWVATIFSRD IRFANHETLQ VIYPYTPQND DELELTPGDF IFMSPMEQTS TSEGWIYGTS
LTTGCSGLLP ENYITKADEC STWIFHGSYS ILNTASSNAL SFGDSVLERR QYEDQGLGET
APLTIICQPT QPLRVNSQPG PQKRCLFVCR HGERMDVVFG KYWLSQCFDA KGRYIRTNLN
MPHSLPQRSG GFRDYEKDAP ITVFGCMQAR LVGEALLESN TIIDHVYCSP SLRCVQTAYN
ILKGLQQENH LKIRVEPGLF EWTKWVPGNT LPAWIPPSEL AAANLSVDTT YRPHIPVSKL
VVSESYDTYI SRSFQVTKEI ISECKSKGNN ILIVAHASSL EACTCQLQGL SPQNSKDFVQ
MVRKIPYLGF CSCEELGETG IWQLTDPPIL PLTHGPTGGF NWRETLLQE
//
