ID M3Y3Q4_MUSPF Unreviewed; 2602 AA.
AC M3Y3Q4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Collagen type VI alpha 5 chain {ECO:0000313|Ensembl:ENSMPUP00000005955.1};
GN Name=COL6A5 {ECO:0000313|Ensembl:ENSMPUP00000005955.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005955.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Collagen VI acts as a cell-binding protein.
CC {ECO:0000256|ARBA:ARBA00043858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the type VI collagen family.
CC {ECO:0000256|ARBA:ARBA00044000}.
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DR EMBL; AEYP01103433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01103442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004781784.1; XM_004781727.2.
DR STRING; 9669.ENSMPUP00000005955; -.
DR Ensembl; ENSMPUT00000006060.1; ENSMPUP00000005955.1; ENSMPUG00000006007.1.
DR GeneID; 101672161; -.
DR KEGG; mpuf:101672161; -.
DR CTD; 256076; -.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000162990; -.
DR HOGENOM; CLU_000182_0_0_1; -.
DR InParanoid; M3Y3Q4; -.
DR OMA; PCWKEKC; -.
DR OrthoDB; 5359724at2759; -.
DR CDD; cd01472; vWA_collagen; 2.
DR CDD; cd01450; vWFA_subfamily_ECM; 5.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR PANTHER; PTHR22588:SF8; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00092; VWA; 9.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF53300; vWA-like; 10.
DR PROSITE; PS50234; VWFA; 9.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2602
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004044256"
FT DOMAIN 30..206
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 234..411
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 440..610
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 626..795
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 812..989
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1003..1176
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1753..1898
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1955..2146
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2280..2474
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1397..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1702..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2251..2271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2576..2602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2582..2602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2602 AA; 287655 MW; E4C95587E4B7CB97 CRC64;
MKILLITFIL ILWTETLADH SPEPGPEYAD VVFLVDSSDH LGTKSFSFVK TFMNKMISSL
PIEAHKYRVA LAQYSDQFHN EFQLSTFRSR NPMLNHLKKN FGFVGGSLRI GHALREAHRT
YFSAQAGGRD KKQFPPILVV LASGESEDDV EEASKALRED GVRIVSVGLQ GASEEQLKAM
ATAQFHFKLR SVRDLGAFSQ NMTQIIKEAT QYRGGAADIQ VSFPVACQKD SLADLVFLVD
ESVGTRQNLR NLQNFLRNIT AAMDVSYNCT RLGLMSYSDR AKIISFLNSS TTQYEFQEQI
QKLSIQAGKS NAGAAIEKMR LEAFSESSGS RRAQGVPQIA VFVTHRPSTD EVRDMAIQLR
LQDVTVFGMN IQGANDVQLE EIVSYPPRQM VSKLESYADL EAYSKNFRKK LQNEIWSQIS
TRAEGMDLDR TGCMDTKEAD IYFLIDGSTS IQKKHFGQIK EFMLAVTGMF SIGPDKVQVG
AVQYSHKMKV EFYINDSSNN VNLRNAILNI EQLKGRTHTG EALDFVLSII KEDRKHRTRQ
VPCYLIVLTD GRSTDEVLKP AERVRAEQVT IHAVGIGEAN KAQLQQIAGG EERVSFGQNF
DALRSIKNEV VHRICKEKGC EGMKADIMFL VDSSGSIGHD NFGKMKTFMK NLLAKIQIGP
ERSHIGVIQF SDQTQEEFQL NKYFTQNEIS DSIDRMSLIN RNTLTGNALT SIDEYFTPAK
GARAMAKKFL ILITDGEAQD PVRDPAKALR DKGVVIFSVG VYGANRTQLE EISGDGSLVF
QVEKFDDLKT IESKLIFRVC ALHDCKNIKV LDIVFVLDHS GSINTEEQES MMDLTIHLVK
KADVGSARVR IGALKYSEYP EVLFHLGKYS NRSAVIEHLR RRRDTGGRTF TARALDHTNI
MFTEEHGSRI QQNVKQMLII ITDGESDDRN QLNDTALKLR NKGIDIYAVG IGKANQLELE
AMAGNKNNTF HVDNFNKLKD LYLPLQERMC TIALEPCDIQ EADMVFFFDG SDMVSHSEFV
TMTTFVSDLI DNFNLQNQRI KIGLAQFGSG FQKIIELKNS LTIPKLKTQI QTITKSNGFP
RIDLALKKVK VMFDPSSGGR RNAGVLQTLV VITSRDPYYN VADEVKVLRN LGICVLVWGI
GDVHKEQLLP MTGDSRKIIT LKDFNTLTDV GIKKRMVREI CQSCGTTNCF MDIVVGFDIS
THLLGQPLFY GHPLLESYLP SILEDITSIG RVSCGAGTEV QVNVAFKVNS ITAKFQLYQR
AIFDSLRQVN VDGPTHLNAQ FLQSLWETFN DRAKSHGQVL LIFSDGLGGE SEIMLEDQSD
RLRAAGLDAL LVVSLNTTAH DEFSSFEFGK GFDYRTHLTI GMRELGKMLS QYLGNIAEKT
CCCTLCKCLG DPGPRGSRGL QATKGFAGLK GSRGHRGDDG DPGRRGESGP PGDKGIAGCP
GEHGQKGIRG FSGSKGEQGE DGVAGLDGEE GFRGFPGEKG EKGDPGSQGS PGSRGPPGEY
GEKGFPGDSG DPGQNSNIKG QKGSKGEQGR QGRTGQKGTP GSPNSRGNRG REGQRGPPGA
SGEPGNRGPQ GLPGTNGLQG PQGLDGIPGR KGEKGSEGHK GPQGSSGPVG AKGNIGSPGP
SGKKGEPGIL GDPGPMGQVG QRGRQGDYGI PGYGQMGRKG VKGPRGFPGD MGQKGAVGDR
GIPGGPGPKG FRGLTLTVGL KGEQGPPGPP GPPGQRGMKG MAGKPVYSQC DLIQFLRDHS
PCWKERCPVY PTELVFALDQ SYDISKQRFD EMREVIKSIV EGLNIRESNC PVGARVVVVS
YDSGTSYLIR GSDYRNKKQL LQLISQLKYR TPTEARDIGN AMRFVARNVF KRTHAGANVR
KVAVFFSNGQ VASQSSIITA TMEFNALDIS PAVFAFNERT FLEAFEFDDT GTFQVIPVSP
NESLEKFQRC TLCYDKCFPN ACIKEIFLPE NSYMDAAFLL DNPQTIANDE FNAVKTLMSS
MIDNFNIASD PGISDFGDRI ALLSYSPWDN SRRKKAVVKA EFGFTTYNSG VLMKRHIQSS
LQQLKGEATI GHTLLWAVEN LFPQTPNLRK HKVIFVISVG EYHERKELLK RVALRAKCQG
YVIFVISLGS AYKEDMEELA SYPLDHHLIQ LGRIHKPDLD YITKFLKPFV YSVRRGFNEY
PPPELENACR LISEEAYQNS DHLFTPEPHD ISSGENSFIG QELSAGKDSS FVLEDIGSDS
LVYIPSHMLM PQELKITHKK GHNSQEIASL TSGHENHGRK EEPGLTNEPG DTSLQEYYMD
VAFLIDASQR IGNDEFQEVK AFLISVLDYF RVASYPLTSM LGDRVAVVSY SPPGYMPNSE
ECPVYLEFDL VTYNNVHQMK HHLQDSFQQL NGDVFIGHAL QWTIDNVFVG TPNLRKNKVI
FVISAGKTNP LDKEVLRNVA LRAKCQGYTI FVFSFGPIHN DKELEELASH PLDHHLVQLG
RIHKPDLNYI IKFVKPFVHL IRRAINKYPP ADLRPKCVNI TSPNPENVGS GNNAFHIPEV
YKIETGNSEL FDEFGSQDQH SFVLGISPSN GSETATDLIQ MLYLLFSTGE LLVNNEKEAQ
SEEMPALADG KQQDKKDGED SR
//
