ID M3Y3V4_MUSPF Unreviewed; 1111 AA.
AC M3Y3V4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Rho GTPase activating protein 39 {ECO:0000313|Ensembl:ENSMPUP00000006005.1};
GN Name=ARHGAP39 {ECO:0000313|Ensembl:ENSMPUP00000006005.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000006005.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000006005.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
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DR EMBL; AEYP01096797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01096798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01096799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01096800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01096801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01096802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01096803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004779436.1; XM_004779379.2.
DR RefSeq; XP_012904879.1; XM_013049425.1.
DR AlphaFoldDB; M3Y3V4; -.
DR STRING; 9669.ENSMPUP00000006005; -.
DR Ensembl; ENSMPUT00000006110.1; ENSMPUP00000006005.1; ENSMPUG00000006056.1.
DR eggNOG; ENOG502QR6X; Eukaryota.
DR GeneTree; ENSGT00390000003161; -.
DR HOGENOM; CLU_005171_0_0_1; -.
DR InParanoid; M3Y3V4; -.
DR OMA; FMEVSKW; -.
DR OrthoDB; 5480623at2759; -.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0099173; P:postsynapse organization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04389; RhoGAP_KIAA1688; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF1; RHO GTPASE-ACTIVATING PROTEIN 39; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
FT DOMAIN 63..97
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 719..871
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 918..1106
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1111 AA; 124756 MW; FE054B0A3E234C17 CRC64;
MSQTRDYECE SHDAGAQEPR VAGSSTRLEW VEIIEPRTRE RMYANLVTGE CVWDPPAGVR
IKRTSENQWW ELFDPNTSRF YYYNASTQRT VWHRPQDCDI IPLAKLQTLK QNTESPRASA
ENSPGRASSV SREGSTSSSL EPELDAGEKA QEPVGRASRQ AAFGALKEES GSSSPPGVFL
EKDYEIYRDY NADGQLLHYR TSSLRWNSGT KERMLIKVAD REPSFLSSQG NGYALDSHAG
SRSRRPSGGQ HSPSLQTFAQ DSDGPVFFPE RRPSPFLKRA ELGSCSPLLA QPRKPTSDSQ
PSSPRYAYEP PLYEEPPVEY QAPIYDEPPM DVQYEAGGGY QAASPQRSPG RKPAPFPQAP
KQGSSPSQQL VLTRQRCPDR FLSLEYSPAG KEYVRQLVYV EQAGSSPKLR AGPRHKYAPS
PGGGSLPLQP SPCLLRDQRL GVSSGDYSSM EGPEPRHTQP PMQVPQAQDD TMSWSSQQDT
MSSTSYSPGT RKRKSRNASL CRAPSTSAAE GAGDRDLLGE QPLAEERPLC GPSLAPVKRA
EGKTGEAEPF LAQARLAWEA QQAHFHMKQR GSWDSQQDGS GYESDSAVPL PMPGPVVRAF
SEDEALAQQD GKHWQRGALE RLAFPQILLE KSVSVQTNLA SPEPYLHPSQ SEDLGSCAQF
ESSRQARSVM PSASCVFPPF TLRKPSSETD IENWASKHFN THTQGLFRRK VSIANMLAWS
SESIKKPMIV TSDRHVKKEA CEIFKLIQMY MGDRRAKADP LHVALEIATK GWSVQGLRDE
LYIQLCRQTT ENFRLESLAR GWELMAICLA FFPPTPKFHS YLEGYIYRHM DPVNDTKVTR
HMKALLERNT KKKSKLRKKP KPYVEEPHGV AISTYAKYCY HKLQKAALTG AKKGLKKPNV
EEIRHAKNAV FSPSMFGSGL QEVMNMQKER YPERQLPWVQ TRLSEEVLAL NGDQTEGIFR
VPGDIDEVNA LKLQVDQWKV PTGLEDPHVP ASLLKLWYRE LEEPLIPHEF YEQCIAHYEN
PEAAVAVVHA LPRINRLVLC YLIRFLQVFV QPANVAITKM DVSNLAMVMA PNCLRCRSDD
PRVIFENTRK EMSFLRVLIQ HLDTSFMEGV L
//
